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Clinical Trial
. 1989:475-8.

[Post-traumatic edema as a limiting factor in early functional treatment measures and its pharmacodynamic modification]

[Article in German]
R Nissen  1 , S Loeschke, A Peters
Affiliations
  • PMID: 2485152
Clinical Trial

[Post-traumatic edema as a limiting factor in early functional treatment measures and its pharmacodynamic modification]

[Article in German]
R Nissen et al. Langenbecks Arch Chir Suppl II Verh Dtsch Ges Chir. 1989.

Abstract

Post-traumatic oedema is a limiting factor of early functional exercise following fractures. A review of drug prophylaxis used in many clinical studies is given. A 30% reduction of oedema development following bimalleolar fractures was achieved with cyclooxigenase inhibitors (azapropazone) and aprotinin. It is pointed out that non-steroidal antiphlogistic drugs inhibit the collagen metabolism during the healing of rat skin-wounds.

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