Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Jul;92(7):697-707.
doi: 10.1007/s00109-014-1165-y. Epub 2014 May 23.

Oncogenic drivers, targeted therapies, and acquired resistance in non-small-cell lung cancer

Arjan Gower  1 , Yisong Wang, Giuseppe Giaccone
Affiliations
Review

Oncogenic drivers, targeted therapies, and acquired resistance in non-small-cell lung cancer

Arjan Gower et al. J Mol Med (Berl). 2014 Jul.

Abstract

In the past decade, a shift toward targeted therapies in non-small-cell lung cancer following molecular profiling has dramatically changed the way advanced adenocarcinoma is treated. However, tumor cells inevitably acquire resistance to such therapies, circumventing any sustained clinical benefit. As the genomic classification of lung cancer continues to evolve and as the mechanisms of acquired resistance to targeted therapies become elucidated and more improved target-specific drugs come into sight, the future will see more promising results from the clinic through the development of new therapeutic strategies to overcome, or prevent the development of, resistance for lung cancer patients.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: The authors declare that they have no conflict of interests.

Figures

Fig. 1
Fig. 1
The pie chart summarizes the prevalence of genetic mutations in adenocarcinoma of the lung
See this image and copyright information in PMC

References

    1. Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin. 2014;64:9–29. - PubMed
    1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90. - PubMed
    1. Shames D, Wistuba I. The evolving genomic classification of lung cancer. J Pathol. 2014;232:121–133. - PMC - PubMed
    1. American Cancer Society. Cancer facts and figures 2012. 2012 [Accessed January 13, 2014]. Available from: http://www.cancer.org/acs/groups/content/@epidemiologysurveilance/docume....
    1. Hrustanovic G, Lee B, Bivona T. Mechanisms of resistance to EGFR targeted therapies. Cancer Biol Ther. 2013;14:304–314. - PMC - PubMed

Publication types

MeSH terms

Substances