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. 2014 May 22;9(5):e97865.
doi: 10.1371/journal.pone.0097865. eCollection 2014.

Evaluation of Finnish Diabetes Risk Score in screening undiagnosed diabetes and prediabetes among U.S. adults by gender and race: NHANES 1999-2010

Lu Zhang  1 , Zhenzhen Zhang  2 , Yurong Zhang  3 , Gang Hu  4 , Liwei Chen  5
Affiliations

Evaluation of Finnish Diabetes Risk Score in screening undiagnosed diabetes and prediabetes among U.S. adults by gender and race: NHANES 1999-2010

Lu Zhang et al. PLoS One. .

Abstract

Objective: To evaluate the performance of Finnish Diabetes Risk Score (FINDRISC) in detecting undiagnosed diabetes and prediabetes among U.S. adults by gender and race.

Methods: This cross-sectional analysis included participants (aged ≥20 years) from the National Health and Nutrition Examination Survey (NHANES) 1999-2010. Sensitivity, specificity, area under the receiver operating characteristic (ROC) curve and the optimal cutoff points for identifying undiagnosed diabetes and prediabetes were calculated for FINDRISC by gender and race/ethnicity.

Results: Among the 20,633 adults (≥20 years), 49.8% were women and 53.0% were non-Hispanic White. The prevalence of undiagnosed diabetes and prediabetes was 4.1% and 35.6%, respectively. FINDRISC was positively associated with the prevalence of diabetes (OR = 1.48 for 1 unit increase, p<0.001) and prediabetes (OR = 1.15 for 1 unit increase, p<0.001). The area under ROC for detecting undiagnosed diabetes was 0.75 for total population, 0.74 for men and 0.78 for women (p = 0.04); 0.76 for White, 0.76 for Black and 0.72 for Hispanics (p = 0.03 for White vs. Hispanics). The area under ROC for detecting prediabetes was 0.67 for total population, 0.66 for men and 0.70 for women (p<0.001); 0.68 for White, 0.67 for Black and 0.65 for Hispanics (p<0.001 for White vs. Hispanics). The optimal cutoff point was 10 (sensitivity = 0.75) for men and 12 (sensitivity = 0.72) for women for detecting undiagnosed diabetes; 9 (sensitivity = 0.61) for men and 10 (sensitivity = 0.69) for women for detecting prediabetes.

Conclusions: FINDRISC is a simple and non-invasive screening tool to identify individuals at high risk for diabetes in the U.S. adults.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Prevalence of diabetes (A and B) and prediabetes (C and D) by Finnish Diabetes Risk Score (FINDRISC) by gender and race/ethnicity, in US men and women aged 20 years or above, NHANES 1999–2010.
The prevalence of diabetes (including diagnosed and undiagnosed diabetes) was calculated among all participants; the prevalence of prediabetes was calculated among participants excluding the diagnosed and undiagnosed diabetes.
Figure 2
Figure 2. Receiver operating characteristic (ROC) curve for identifying undiagnosed diabetes (A and B) and prediabetes (C and D) by gender and race/ethnicity in US men and women aged 20 years or above, NHANES 1999–2010.
See this image and copyright information in PMC

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