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. 2014 Jul 7;6(13):7325-31.
doi: 10.1039/c4nr00460d.

In vitro dosimetry of agglomerates

V Hirsch  1 , C Kinnear, L Rodriguez-Lorenzo, C A Monnier, B Rothen-Rutishauser, S Balog, A Petri-Fink
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In vitro dosimetry of agglomerates

V Hirsch et al. Nanoscale. .

Abstract

Agglomeration of nanoparticles in biological fluids is a pervasive phenomenon that leads to difficulty in the interpretation of results from in vitro exposure, primarily due to differing particokinetics of agglomerates to nanoparticles. Therefore, well-defined small agglomerates were designed that possessed different particokinetic profiles, and their cellular uptake was compared to a computational model of dosimetry. The approach used here paves the way for a better understanding of the impact of agglomeration on the nanoparticle-cell interaction.

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