Review

. 2014 May 19;19(5):6393-406.

doi: 10.3390/molecules19056393.

The role of micro-RNAs in hepatocellular carcinoma: from molecular biology to treatment

Marco D'Anzeo¹, Luca Faloppi², Mario Scartozzi³, Riccardo Giampieri⁴, Maristella Bianconi⁵, Michela Del Prete⁶, Nicola Silvestris⁷, Stefano Cascinu⁸

Affiliations

¹ Department of Medical Oncology, Università Politecnica delle Marche, A.O.U. "Ospedali Riuniti" Via Conca 71, 60126 Ancona, Italy. m.danzeo@gmail.com.
² Department of Medical Oncology, Università Politecnica delle Marche, A.O.U. "Ospedali Riuniti" Via Conca 71, 60126 Ancona, Italy. lucafaloppi@gmail.com.
³ Department of Medical Oncology, Università Politecnica delle Marche, A.O.U. "Ospedali Riuniti" Via Conca 71, 60126 Ancona, Italy. marioscartozzi@gmail.com.
⁴ Department of Medical Oncology, Università Politecnica delle Marche, A.O.U. "Ospedali Riuniti" Via Conca 71, 60126 Ancona, Italy. kakeru@libero.it.
⁵ Department of Medical Oncology, Università Politecnica delle Marche, A.O.U. "Ospedali Riuniti" Via Conca 71, 60126 Ancona, Italy. stellabianconi@gmail.com.
⁶ Department of Medical Oncology, Università Politecnica delle Marche, A.O.U. "Ospedali Riuniti" Via Conca 71, 60126 Ancona, Italy. micheladelprete@gmail.com.
⁷ Istituto Oncologico "Giovanni Paolo II", I.R.C.S.S. Ospedale Oncologico di Bari, Viale Orazio Flacco 65, 70124 Bari, Italy. n.silvestris@oncologico.bari.it.
⁸ Department of Medical Oncology, Università Politecnica delle Marche, A.O.U. "Ospedali Riuniti" Via Conca 71, 60126 Ancona, Italy. cascinu@yahoo.com.

PMID: 24853455
PMCID: PMC6271763
DOI: 10.3390/molecules19056393

Review

The role of micro-RNAs in hepatocellular carcinoma: from molecular biology to treatment

Marco D'Anzeo et al. Molecules. 2014.

. 2014 May 19;19(5):6393-406.

doi: 10.3390/molecules19056393.

Authors

Marco D'Anzeo¹, Luca Faloppi², Mario Scartozzi³, Riccardo Giampieri⁴, Maristella Bianconi⁵, Michela Del Prete⁶, Nicola Silvestris⁷, Stefano Cascinu⁸

Affiliations

¹ Department of Medical Oncology, Università Politecnica delle Marche, A.O.U. "Ospedali Riuniti" Via Conca 71, 60126 Ancona, Italy. m.danzeo@gmail.com.
² Department of Medical Oncology, Università Politecnica delle Marche, A.O.U. "Ospedali Riuniti" Via Conca 71, 60126 Ancona, Italy. lucafaloppi@gmail.com.
³ Department of Medical Oncology, Università Politecnica delle Marche, A.O.U. "Ospedali Riuniti" Via Conca 71, 60126 Ancona, Italy. marioscartozzi@gmail.com.
⁴ Department of Medical Oncology, Università Politecnica delle Marche, A.O.U. "Ospedali Riuniti" Via Conca 71, 60126 Ancona, Italy. kakeru@libero.it.
⁵ Department of Medical Oncology, Università Politecnica delle Marche, A.O.U. "Ospedali Riuniti" Via Conca 71, 60126 Ancona, Italy. stellabianconi@gmail.com.
⁶ Department of Medical Oncology, Università Politecnica delle Marche, A.O.U. "Ospedali Riuniti" Via Conca 71, 60126 Ancona, Italy. micheladelprete@gmail.com.
⁷ Istituto Oncologico "Giovanni Paolo II", I.R.C.S.S. Ospedale Oncologico di Bari, Viale Orazio Flacco 65, 70124 Bari, Italy. n.silvestris@oncologico.bari.it.
⁸ Department of Medical Oncology, Università Politecnica delle Marche, A.O.U. "Ospedali Riuniti" Via Conca 71, 60126 Ancona, Italy. cascinu@yahoo.com.

PMID: 24853455
PMCID: PMC6271763
DOI: 10.3390/molecules19056393

Abstract

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third leading cause of cancer deaths. microRNAs (miRNAs) are evolutionary conserved small non-coding RNA that negatively regulate gene expression and protein translation. Recent evidences have shown that they are involved in many biological processes, from development and cell-cycle regulation to apoptosis. miRNAs can behave as tumor suppressor or promoter of oncogenesis depending on the cellular function of their targets. Moreover, they are frequently dysregulated in HCC. In this review we summarize the latest findings of miRNAs regulation in HCC and their role as potentially diagnostic and prognostic biomarkers for HCC. We highlight development of miRNAs as potential therapeutic targets for HCC.

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Conflict of interest statement

The authors declare no conflict of interest.

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The role of micro-RNAs in hepatocellular carcinoma: from molecular biology to treatment

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The role of micro-RNAs in hepatocellular carcinoma: from molecular biology to treatment

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