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Comment
. 2014 Jun;63(6):1826-8.
doi: 10.2337/db14-0283.

Timing is everything: implications for metabolic consequences of sleep restriction

Christopher S Colwell  1 , Aleksey V Matveyenko  2
Affiliations
Comment

Timing is everything: implications for metabolic consequences of sleep restriction

Christopher S Colwell et al. Diabetes. 2014 Jun.
No abstract available

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Figures

Figure 1
Figure 1
A: A number of recent studies indicate a close, interconnected relationship between sleep, circadian rhythms, and metabolism—or the “inseparable triad.” B: Disruption of sleep and circadian rhythms are gaining greater appreciation as risk factors for T2D. These disruptions promote global insulin resistance, inflammation, and loss of pancreatic β-cell function. Leproult et al. (13) suggest that sleep loss and circadian disruption independently contribute to metabolic abnormalities associated with T2D. Could the inseparable triad be broken apart? The study raises a number of important questions about the underlying mechanisms, including the role of specific organ systems (liver, skeletal muscle, or central nervous system), in quickly developed insulin resistance. Identification of the mechanistic link between circadian disruption and impaired β-cell secretory function, growth, and survival also seems to be a research priority. Finally, we need to understand whether T2D per se contributes to sleep and circadian disruption, and thus promotes a viscous cycle of metabolic abnormalities and sleep/wake disturbances in patients with T2D.
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