[High risk indication of postoperative chemotherapy in early stage non-small cell lung cancer]

Abstract

Background and objective: More than 35% Ib stage lung cancers have metastasised or recurrenced after operation, whose prognosis still remain poor. There're much controversy over the necessity of adjuvant chemotherapy to them. This aim of this study is investigated the clinical and pathological characters influencing prognosis of the stage Ib non-small cell lung cancer (NSCLC) and to explore the indication of postoperative chemotherapy.

Methods: NSCLC patients (281 cases) who underwent lobectomy were examined. Cox proportional-hazards ratios were used to identify independent prognostic factors for survival. Kaplan-Meier survival curves were calculated to estimate survival rates.

Results: Kaplan-Meier analysis show that, cancerous embolus in the blood vessel or lymphatic vessel, histologic grade and tumor location were remarkerbly associated with mortality risk (P<0.05). The poor histologic grade and cancerous embolus in the blood vessel were closely associated with increased mortality risk on multivariate analysis in stage Ib NSCLC.

Conclusions: The low histologic grade and cancerous embolus in the blood vessel or lymphatic vessel are closely correlated with survival in the stage Ib NSCLC and can be an index for the postoperative chemotherapy.

1

生存分析。A：281例Ⅰb期肺癌患者生存时间分析；B：手术方式对患者生存的影响；C：肿瘤细胞分化程度对患者生存的影响；D：淋巴管内癌栓对患者生存的影响；E：血管内癌栓对患者生存的影响。 Survival time analysis. A: survival time analysis of 281 patients with stage Ⅰb lung cancer; B: the influence of operation methods for patients survival; C: the impact of tumor cell differentiation degree on patients survival; D: the impact of lymphatic tumor emboli on patients survival; E: the impact of intravascular tumor emboli on patients survival.