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Comment
. 2014 May 22;123(21):3217-8.
doi: 10.1182/blood-2014-04-562223.

The iron fist: malaria and hepcidin

Affiliations
Comment

The iron fist: malaria and hepcidin

Narla Mohandas et al. Blood. .

Abstract

In this issue of Blood, Atkinson and colleagues document dynamic fluctuations in plasma concentrations of hepcidin, the master regulator of iron homeostasis, in African children during malaria transmission season and further show that low hepcidin levels and iron deficiency are more prevalent at the end of the malaria season, implying that iron therapy may be most beneficial at this time.

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Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Comment on

References

    1. Atkinson SH, Armitage AE, Khandwala S, et al. Combinatorial effects of malaria season, iron deficiency, and inflammation determine plasma hepcidin concentration in African children. Blood. 2014;123(21):3221–3229. - PMC - PubMed
    1. Sazawal S, Black RE, Ramsan M, et al. Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial. Lancet. 2006;367(9505):133–143. - PubMed
    1. Soofi S, Cousens S, Iqbal SP, et al. Effect of provision of daily zinc and iron with several micronutrients on growth and morbidity among young children in Pakistan: a cluster-randomised trial. Lancet. 2013;382(9886):29–40. - PubMed
    1. Ganz T. Hepcidin and iron regulation, 10 years later. Blood. 2011;117(17):4425–4433. - PMC - PubMed
    1. Camaschella C. Iron and hepcidin: a story of recycling and balance. Hematology Am Soc Hematol Educ Program. 2013;2013:1–8. - PubMed