The iron fist: malaria and hepcidin
- PMID: 24855192
- PMCID: PMC4046432
- DOI: 10.1182/blood-2014-04-562223
The iron fist: malaria and hepcidin
Abstract
In this issue of Blood, Atkinson and colleagues document dynamic fluctuations in plasma concentrations of hepcidin, the master regulator of iron homeostasis, in African children during malaria transmission season and further show that low hepcidin levels and iron deficiency are more prevalent at the end of the malaria season, implying that iron therapy may be most beneficial at this time.
Conflict of interest statement
Conflict-of-interest disclosure: The authors declare no competing financial interests.
Comment on
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Combinatorial effects of malaria season, iron deficiency, and inflammation determine plasma hepcidin concentration in African children.Blood. 2014 May 22;123(21):3221-9. doi: 10.1182/blood-2013-10-533000. Epub 2014 Mar 4. Blood. 2014. PMID: 24596418 Free PMC article.
References
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- Soofi S, Cousens S, Iqbal SP, et al. Effect of provision of daily zinc and iron with several micronutrients on growth and morbidity among young children in Pakistan: a cluster-randomised trial. Lancet. 2013;382(9886):29–40. - PubMed
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- Camaschella C. Iron and hepcidin: a story of recycling and balance. Hematology Am Soc Hematol Educ Program. 2013;2013:1–8. - PubMed
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