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Comment
. 2014 Jul 1;33(13):1423-4.
doi: 10.15252/embj.201488815. Epub 2014 May 22.

Epithelial regeneration and cancer: news from the Src front

Pedro Sousa-Victor  1 , Heinrich Jasper  1
Affiliations
Comment

Epithelial regeneration and cancer: news from the Src front

Pedro Sousa-Victor et al. EMBO J. .

Abstract

Src family kinases (SFKs) have long been implicated in tumorigenesis, but the exact requirement for individual kinase members, and their specific spatially and temporally defined roles in the maintenance of epithelial homeostasis remained unclear. A study by Cordero et al (2014) now combines the strengths of Drosophila and mouse models for intestinal epithelial regeneration to characterize the role of individual SFKs in epithelial stem cells, tissue regeneration, and tumorigenesis.

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Figures

Figure 1
Figure 1. Model for the integration of SFKs in the control of ISC proliferation in flies and mice
See text for details. APC, adenomatous polyposis coli; EC, enterocyte; EE, enteroendocrine cells; EB, enteroblast; ISC, intestinal stem cell; TA, transit amplifying cell population; SFKs, Src family kinases.
See this image and copyright information in PMC

Comment on

  • c-Src drives intestinal regeneration and transformation.
    Cordero JB, Ridgway RA, Valeri N, Nixon C, Frame MC, Muller WJ, Vidal M, Sansom OJ. Cordero JB, et al. EMBO J. 2014 Jul 1;33(13):1474-91. doi: 10.1002/embj.201387454. Epub 2014 Apr 30. EMBO J. 2014. PMID: 24788409 Free PMC article.

References

    1. Biteau B, Hochmuth CE, Jasper H. Maintaining tissue homeostasis: dynamic control of somatic stem cell activity. Cell Stem Cell. 2011;9:402–411. - PMC - PubMed
    1. Cordero JB, Stefanatos RK, Myant K, Vidal M, Sansom OJ. Non-autonomous crosstalk between the Jak/Stat and Egfr pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut. Development. 2012;139:4524–4535. - PubMed
    1. Cordero JB, Ridgway RA, Valeri N, Nixon C, Frame MC, Muller WJ, Vidal M, Sansom OJ. c-Src drives intestinal regeneration and transformation. EMBO J. 2014;33:1474–1491. - PMC - PubMed
    1. Gargalionis AN, Karamouzis MV, Papavassiliou AG. The molecular rationale of Src inhibition in colorectal carcinomas. Int J Cancer. 2014;134:2019–2029. - PubMed
    1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90. - PubMed

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