Die another day: a painless path to longevity

doi:10.1016/j.cell.2014.05.013

Comment

. 2014 May 22;157(5):1004-6.

doi: 10.1016/j.cell.2014.05.013.

Die another day: a painless path to longevity

Sophie M Steculorum¹, Jens C Brüning²

Affiliations

¹ Max-Planck-Institute for Neurological Research, Gleueler Strasse 50a, 50931 Köln, Germany; Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne and Center for Molecular Medicine Cologne (CMMC), Zülpicher Strasse 47a, 50674 Köln, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Ageing Associated Diseases (CECAD), Zülpicher Str. 47a, 50674 Köln, Germany.
² Max-Planck-Institute for Neurological Research, Gleueler Strasse 50a, 50931 Köln, Germany; Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne and Center for Molecular Medicine Cologne (CMMC), Zülpicher Strasse 47a, 50674 Köln, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Ageing Associated Diseases (CECAD), Zülpicher Str. 47a, 50674 Köln, Germany. Electronic address: bruening@nf.mpg.de.

PMID: 24855937
DOI: 10.1016/j.cell.2014.05.013

Free article

Comment

Die another day: a painless path to longevity

Sophie M Steculorum et al. Cell. 2014.

Free article

. 2014 May 22;157(5):1004-6.

doi: 10.1016/j.cell.2014.05.013.

Authors

Sophie M Steculorum¹, Jens C Brüning²

Affiliations

¹ Max-Planck-Institute for Neurological Research, Gleueler Strasse 50a, 50931 Köln, Germany; Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne and Center for Molecular Medicine Cologne (CMMC), Zülpicher Strasse 47a, 50674 Köln, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Ageing Associated Diseases (CECAD), Zülpicher Str. 47a, 50674 Köln, Germany.
² Max-Planck-Institute for Neurological Research, Gleueler Strasse 50a, 50931 Köln, Germany; Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne and Center for Molecular Medicine Cologne (CMMC), Zülpicher Strasse 47a, 50674 Köln, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Ageing Associated Diseases (CECAD), Zülpicher Str. 47a, 50674 Köln, Germany. Electronic address: bruening@nf.mpg.de.

PMID: 24855937
DOI: 10.1016/j.cell.2014.05.013

Abstract

Riera et al. identify a neuroendocrine circuit that controls longevity and the age-dependent onset of metabolic decline via the pain-transducing channel TRPV1. Thus, pharmacological inhibition of TRPV1 may provide a new approach to treat not only metabolic disorders but also a broader range of age-related pathologies.

PubMed Disclaimer

Comment on

TRPV1 pain receptors regulate longevity and metabolism by neuropeptide signaling.
Riera CE, Huising MO, Follett P, Leblanc M, Halloran J, Van Andel R, de Magalhaes Filho CD, Merkwirth C, Dillin A. Riera CE, et al. Cell. 2014 May 22;157(5):1023-36. doi: 10.1016/j.cell.2014.03.051. Cell. 2014. PMID: 24855942

Cited by

Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets.
Achanta S, Jordt SE. Achanta S, et al. Ann N Y Acad Sci. 2020 Nov;1480(1):73-103. doi: 10.1111/nyas.14472. Epub 2020 Sep 6. Ann N Y Acad Sci. 2020. PMID: 32892378 Free PMC article.
Common methods of biological age estimation.
Jia L, Zhang W, Chen X. Jia L, et al. Clin Interv Aging. 2017 May 11;12:759-772. doi: 10.2147/CIA.S134921. eCollection 2017. Clin Interv Aging. 2017. PMID: 28546743 Free PMC article. Review.
Construction Formula of Biological Age Using the Principal Component Analysis.
Jia L, Zhang W, Jia R, Zhang H, Chen X. Jia L, et al. Biomed Res Int. 2016;2016:4697017. doi: 10.1155/2016/4697017. Epub 2016 Dec 6. Biomed Res Int. 2016. PMID: 28050560 Free PMC article. Review.

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

LinkOut - more resources

Full Text Sources
- Elsevier Science
Other Literature Sources
- scite Smart Citations

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Die another day: a painless path to longevity

Affiliations

Die another day: a painless path to longevity

Authors

Affiliations

Abstract

Comment on

Similar articles

Cited by

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources