Limitations of preimplantation genetic diagnosis for mitochondrial DNA diseases

Affiliations

¹ Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA; Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address: mitalipo@ohsu.edu.
² Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR 97239, USA.
³ Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
⁴ Divisions of Human Genetics and Metabolic Disease, Department of Pediatrics, The Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

Comment

Shoukhrat Mitalipov et al. Cell Rep. 2014.

. 2014 May 22;7(4):935-7.

doi: 10.1016/j.celrep.2014.05.004.

¹ Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA; Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address: mitalipo@ohsu.edu.
² Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR 97239, USA.
³ Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
⁴ Divisions of Human Genetics and Metabolic Disease, Department of Pediatrics, The Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

No abstract available

Comment on

Rapid mitochondrial DNA segregation in primate preimplantation embryos precedes somatic and germline bottleneck.
Lee HS, Ma H, Juanes RC, Tachibana M, Sparman M, Woodward J, Ramsey C, Xu J, Kang EJ, Amato P, Mair G, Steinborn R, Mitalipov S. Lee HS, et al. Cell Rep. 2012 May 31;1(5):506-15. doi: 10.1016/j.celrep.2012.03.011. Cell Rep. 2012. PMID: 22701816 Free PMC article.
Data from artificial models of mitochondrial DNA disorders are not always applicable to humans.
Steffann J, Gigarel N, Samuels DC, Monnot S, Borghese R, Hesters L, Frydman N, Burlet P, Frydman R, Benachi A, Rotig A, Munnich A, Bonnefont JP. Steffann J, et al. Cell Rep. 2014 May 22;7(4):933-4. doi: 10.1016/j.celrep.2014.05.005. Cell Rep. 2014. PMID: 24856293 No abstract available.

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