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doi: 10.1016/j.celrep.2014.04.041.
How steroids steer T cells
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- PMID: 24856295
- DOI: 10.1016/j.celrep.2014.04.041
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How steroids steer T cells
Cell Rep.
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Free article
Abstract
Recent papers from Mahata et al. and Bereshchenko et al. reveal how steroids steer immune responses by tipping T helper (Th) subset balances and activities. Pregnenolone produced by Th2 cells mediates immunosuppressive responses, and glucocorticoids stimulate regulatory T cell development via the induction of GILZ expression.
Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.
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GILZ promotes production of peripherally induced Treg cells and mediates the crosstalk between glucocorticoids and TGF-β signaling.Cell Rep. 2014 Apr 24;7(2):464-475. doi: 10.1016/j.celrep.2014.03.004. Epub 2014 Apr 3. Cell Rep. 2014. PMID: 24703841
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Single-cell RNA sequencing reveals T helper cells synthesizing steroids de novo to contribute to immune homeostasis.Cell Rep. 2014 May 22;7(4):1130-42. doi: 10.1016/j.celrep.2014.04.011. Epub 2014 May 10. Cell Rep. 2014. PMID: 24813893 Free PMC article.
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