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. 2014 Jun;20(6):1037-9.
doi: 10.3201/eid2006.131430.

Novel human bufavirus genotype 3 in children with severe diarrhea, Bhutan

Takaaki Yahiro, Sonam Wangchuk, Kinlay Tshering, Purushotam Bandhari, Sangay Zangmo, Tshering Dorji, Karchung Tshering, Takashi Matsumoto, Akira Nishizono, Maria Söderlund-Venermo, Kamruddin Ahmed

Novel human bufavirus genotype 3 in children with severe diarrhea, Bhutan

Takaaki Yahiro et al. Emerg Infect Dis. 2014 Jun.

Abstract

We identified a new genotype of bufavirus, BuV3, in fecal samples (0.8%) collected to determine the etiology of diarrhea in children in Bhutan. Norovirus GII.6 was detected in 1 sample; no other viral diarrheal pathogens were detected, suggesting BuV3 as a cause of diarrhea. This study investigates genetic diversity of circulating BuVs.

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Figures

Figure
Figure
Phylogenetic trees of the viral protein 1 (VP1) of bufaviruses, constructed by using deduced amino acid sequences by neighbor-joining method. The full length open reading frames of VP1 genes were used to deduce amino acid sequences. Porcine parvovirus strain NC 001718 was used as an out-group. The numbers adjacent to the nodes represent the bootstrap values, and values <50% are not shown. Scale bar indicates the genetic distances expressed as amino acid substitutions per site. Accession numbers for DNA Data Bank of Japan, European Molecular Biology Laboratory, and GenBank are AB847987, AB847988, and AB847989 for strains BTN-63, BTN-109, and BTN-310, respectively.
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