Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014;24(5):353-60.
doi: 10.2188/jea.je20130195. Epub 2014 May 24.

Low intake of vegetables and fruits and risk of colorectal cancer: the Japan Collaborative Cohort Study

Norihiro Aoyama  1 , Miyuki Kawado, Hiroya Yamada, Shuji Hashimoto, Koji Suzuki, Kenji Wakai, Sadao Suzuki, Yoshiyuki Watanabe, Akiko Tamakoshi
Affiliations

Low intake of vegetables and fruits and risk of colorectal cancer: the Japan Collaborative Cohort Study

Norihiro Aoyama et al. J Epidemiol. 2014.

Abstract
in English, Japanese

Background: The evidence for an association between low intake of vegetables and fruits and increased colorectal cancer risk is inconclusive. Evaluating the colorectal cancer risk associated with continued low intake is important.

Methods: We used data of 45 516 and 14 549 subjects aged 40-79 years obtained in the baseline and interim surveys, respectively, from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study). The intake frequency of vegetables and fruits as assessed by a self-administered questionnaire was classified into tertiles of low, middle, and high groups, and the low group was subdivided into 2 equal groups (lower low and higher low groups). Colorectal cancer incidence determined from follow-up was used. Cox's proportional hazard model was employed to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs), adjusting for covariates.

Results: During 598 605 person-years of subject follow-up after baseline, we identified 806 colorectal cancer cases. HRs for the lower low versus the middle and high intake frequencies of vegetables and fruits at baseline were 0.95 (95% CI 0.77-1.16) and 1.08 (95% CI 0.90-1.29), respectively. During 125 980 person-years of subject follow-up after the interim survey, 197 colorectal cancer cases were identified. HRs for the low versus middle and high intake frequencies of vegetables and fruits in both baseline and interim surveys were 0.91 (95% CI 0.61-1.37) and 0.87 (95% CI 0.59-1.27), respectively.

Conclusions: Our results suggest that low intake and continued low intake of vegetables and fruits are not strongly associated with colorectal cancer risk.

【背景】: 野菜と果物の低摂取と大腸がんの高リスクとの関連についてのエビデンスは必ずしも十分でない。低摂取の継続に対する大腸がんリスクを評価することが重要である。

【方法】: 基礎資料として、JACC Studyにおける40～79歳の45,516人のベースライン調査データと14,549人の中間調査データを用いた。自記式質問票による野菜と果物の摂取頻度を低・中・高摂取頻度に3区分し、低摂取頻度をさらに2つに細分した。追跡調査による大腸がん罹患の有無に基づいて、ハザード比と95％信頼区間を、Cox回帰により交絡変数を調整して推定した。

【結果】: ベースライン後の598,605人年の追跡により、大腸がん罹患806人が観察された。ベースライン時の中・高頻度摂取に対する低頻度摂取（細分の低い方）における大腸がんハザード比は、野菜で0.95（95％信頼区間0.77-1.16）、果物で1.08（95％信頼区間0.90-1.29）であった。一方、中間調査後の125,980人年の追跡により、大腸がん罹患197人が観察された。ベースライン調査と中間調査ともに、中・高頻度摂取の継続に対する低頻度摂取の継続における大腸がんハザード比は、野菜で0.91（95％信頼区間0.61-1.37）、果物で0.87（95％信頼区間0.59-1.27）であった。

【結論】: これらの結果から、野菜と果物の低摂取および低摂取の継続は大腸がんリスクとの強い関連がないことが示唆される。

PubMed Disclaimer

References

    1. Terry P, Giovannucci E, Michels KB, Bergkvist L, Hansen H, Holmberg L, et al. . Fruit, vegetables, dietary fiber, and risk of colorectal cancer. J Natl Cancer Inst. 2001;93:525–33 10.1093/jnci/93.7.525 - DOI - PubMed
    1. McCullough ML, Robertson AS, Chao A, Jacobs EJ, Stampfer MJ, Jacobs DR, et al. . A prospective study of whole grains, fruits, vegetables and colon cancer risk. Cancer Causes Control. 2003;14:959–70 10.1023/B:CACO.0000007983.16045.a1 - DOI - PubMed
    1. Wark PA, Weijenberg MP, van ’t Veer P, van Wijhe G, Lüchtenborg M, van Muijen GN, et al. . Fruits, vegetables, and hMLH1 protein-deficient and -proficient colon cancer: The Netherlands cohort study. Cancer Epidemiol Biomarkers Prev. 2005;14:1619–25 10.1158/1055-9965.EPI-05-0109 - DOI - PubMed
    1. Sato Y, Tsubono Y, Nakaya N, Ogawa K, Kurashima K, Kuriyama S, et al. . Fruit and vegetable consumption and risk of colorectal cancer in Japan: The Miyagi Cohort Study. Public Health Nutr. 2005;8:309–14 10.1079/PHN2004681 - DOI - PubMed
    1. McCarl M, Harnack L, Limburg PJ, Anderson KE, Folsom AR. Incidence of colorectal cancer in relation to glycemic index and load in a cohort of women. Cancer Epidemiol Biomarkers Prev. 2006;15:892–6 10.1158/1055-9965.EPI-05-0700 - DOI - PubMed

Publication types