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. 2014 May 22;12(5):3060-71.
doi: 10.3390/md12053060.

Klymollins T-X, bioactive eunicellin-based diterpenoids from the soft coral Klyxum molle

Fang-Yu Chang  1 , Fang-Jung Hsu  2 , Chi-Jen Tai  3 , Wen-Chi Wei  4 , Ning-Sun Yang  5 , Jyh-Horng Sheu  6
Affiliations

Klymollins T-X, bioactive eunicellin-based diterpenoids from the soft coral Klyxum molle

Fang-Yu Chang et al. Mar Drugs. .

Abstract

Five new eunicellin-based diterpenoids, klymollins T-X (1-5), along with two known compounds (6 and 7) have been isolated from the soft coral Klyxum molle. The structures of these new metabolites were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. Compound 5 was found to exert significant in vitro anti-inflammatory activity against LPS-stimulated RAW264.7 macrophage cells. Furthermore, compounds 4 and 7 were shown to exhibit cytotoxicity against a limited panel of human cancer cell lines.

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Figures

Chart 1
Chart 1
Structures of metabolites 1–7.
Figure 1
Figure 1
Selected COSY (▬) and HMBC (→) correlations of 1, 3 and 4.
Figure 2
Figure 2
Key NOESY Correlations for 1.
Figure 3
Figure 3
Key NOESY Correlations for 3 and 4.
Figure 4
Figure 4
Effect of compounds 1–7 on LPS-induced IL-6 and TNF-α expression in RAW264.7 macrophage cells by ELISA analysis. The values are mean ± SEM. (n = 6). Relative intensity of the LPS alone stimulated group was taken as 100%. * Significantly different from LPS alone stimulated group (P < 0.05). a stimulated with LPS, b stimulated with LPS in the presence of 1–7 (25 μM).
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