Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Aug;1846(1):232-7.
doi: 10.1016/j.bbcan.2014.05.003. Epub 2014 May 22.

Targeted therapy for gastric cancer: molecular pathways and ongoing investigations

Wei Yang  1 , Alexander Raufi  1 , Samuel J Klempner  2
Affiliations
Review

Targeted therapy for gastric cancer: molecular pathways and ongoing investigations

Wei Yang et al. Biochim Biophys Acta. 2014 Aug.

Abstract

Gastric cancer is currently the second leading cause of worldwide cancer mortality. Ongoing collaborative sequencing efforts have highlighted recurrent somatic genomic aberrations in gastric cancer, however, despite advances in characterizing the genomic landscape, there have been few advances in patient outcomes. Prognosis remains poor with a median overall survival of 12 months for advanced disease. The improved survival with trastuzumab, and more recently ramucirumab, underscore the promise of targeted and biologic therapies and the importance of molecular tumor characterization in gastric cancer. Here we review the most frequent actionable alterations in gastric cancer and highlight ongoing clinical investigations attempting to translate biologic understanding into improved clinical outcomes.

Keywords: Cancer; Gastric; Mutation; Proteomics; Sequencing; Targeted therapy.

PubMed Disclaimer

Substances