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Case Reports
. 2014 Sep;147(3):599-601.e1.
doi: 10.1053/j.gastro.2014.05.010. Epub 2014 May 21.

Detection of a sexually transmitted hepatitis C virus protease inhibitor-resistance variant in a human immunodeficiency virus-infected homosexual man

Sandra Franco  1 , Cristina Tural  2 , Maria Nevot  1 , José Moltó  2 , Jürgen Kurt Rockstroh  3 , Bonaventura Clotet  4 , Miguel Angel Martinez  5
Affiliations
Case Reports

Detection of a sexually transmitted hepatitis C virus protease inhibitor-resistance variant in a human immunodeficiency virus-infected homosexual man

Sandra Franco et al. Gastroenterology. 2014 Sep.

Abstract

There is an international epidemic of hepatitis C virus (HCV) infection among human immunodeficiency virus-infected men who have sex with men. Transmission of HCV variants that are resistant to recently approved direct-acting antivirals (DAAs) could be an important clinical and public health problem. We document a case of transmission of a DAA-resistant variant of HCV from a patient who was treated with telaprevir to his sexual partner. The transmission of HCV DAA-resistant variants could impair therapeutic regimens that include DAAs.

Keywords: Cirrhosis; Liver Disease; Transmission.

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