Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Aug;59(8):790-9.
doi: 10.1016/j.archoralbio.2014.05.002. Epub 2014 May 10.

Important aspects regarding the role of microorganisms in bisphosphonate-related osteonecrosis of the jaws

Renata Chiapinotto Boff  1 , Fernanda Gonçalves Salum  1 , Maria Antonia Figueiredo  1 , Karen Cherubini  2
Affiliations
Review

Important aspects regarding the role of microorganisms in bisphosphonate-related osteonecrosis of the jaws

Renata Chiapinotto Boff et al. Arch Oral Biol. 2014 Aug.

Abstract

Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is an important side effect of bisphosphonates, whose etiopathogenesis has not been completely elucidated. Theories pointing to bone turnover and angiogenesis inhibition, as well as effects on epithelial cells of oral mucosa and the role of microorganisms have been reported. Nevertheless, the true contribution of each one of these factors to BRONJ is unknown. We present here a literature review focusing on important aspects regarding the role of microorganisms in BRONJ development. Knowledge about specific microbiota and its role in the etiopathogenesis of this disease can help the optimisation of preventive and therapeutic interventions in patients with or at-risk for BRONJ.

Keywords: Actinomyces sp.; Bisphosphonate; Candida sp.; Infection; Osteonecrosis of the jaws.

PubMed Disclaimer

MeSH terms

LinkOut - more resources