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. 2014:2014:898505.
doi: 10.1155/2014/898505. Epub 2014 Apr 17.

Neurofibroma of the palate

Tirumalasetty Sreenivasa Bharath  1 , Yelamolu Rama Krishna  2 , Govind Rajkumar Nalabolu  1 , Swetha Pasupuleti  1 , Suneela Surapaneni  1 , Suresh Babu Ganta  1
Affiliations

Neurofibroma of the palate

Tirumalasetty Sreenivasa Bharath et al. Case Rep Dent. 2014.

Abstract

Neurofibroma is a benign peripheral nerve sheath tumor comprising variable mixture of Schwann cells, perineurial-like cells, and fibroblasts. Neurofibroma may occur as solitary lesion or as part of a generalised syndrome of neurofibromatosis or very rarely as multiple neurofibromas without any associated syndrome. There are two distinct variants of neurofibromatosis type I and type II. We present a case of neurofibroma of the hard palate associated with neurofibromatosis type I. The diagnosis of the lesion was made based on the clinical findings, family history, histopathology, and immunohistochemistry. Literature was reviewed and different types of neurofibroma, their incidence and frequency in the oral cavity, its association with neurofibromatosis, clinical manifestations, histopathologic characteristics, immunohistochemical analysis, behaviour, treatment, and recurrence are discussed.

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Figures

Figure 1
Figure 1
Diffuse multiple brownish black pigmented nodular masses of various sizes spread all over the body.
Figure 2
Figure 2
Solitary, oval, well-defined palatal swelling.
Figure 3
Figure 3
Fibrocellular connective tissue predominantly elongated spindle shaped with wavy and bent nuclei.
Figure 4
Figure 4
Peripheral nerve tissue within the perineural sheath and dilated blood capillaries.
Figure 5
Figure 5
S-100 immunopositivity.
See this image and copyright information in PMC

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