The effects of sensorial denervation on the ovarian function, by the local administration of capsaicin, depend on the day of the oestrous cycle when the treatment was performed

Abstract

There is evidence that sensory innervation plays a role in the regulation of puberty. The present study investigates the effects of functional sensorial desensitisation induced by capsaicin administration to adult female rats in the days of diestrus 1, diestrus 2, pro-oestrus or oestrus on ovulation and serum oestradiol and progesterone concentration. The animals were allotted at random to one of the following groups: (1) animals with capsaicin administration into the bursa ovarica (local administration) (2) animals with vehicle administration into the bursa ovarica and (3) untreated animals group. The animals treated were killed on the day of oestrus after three consecutive 4-day oestrous cycles. No differences were observed in oestrous cyclicity or the average number of ova shed between the sensorial desensitisation animals and the vehicle-treated groups. Capsaicin administration resulted in a significant increase in the intra-ovarian noradrenaline levels in the day of diestrus 2 and pro-oestrus. Serum oestradiol and progesterone concentrations were different, depending on the day of the oestrous cycle in which the treatment was performed. These results suggest that in adult normal female rats, ovarian sensorial innervations participate together with the sympathetic innervation in the ovarian function regulating the hormone secretion and this participation varies along the oestrous cycle.