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Review
. 2014 Sep:33:81-92.
doi: 10.1016/j.semcdb.2014.05.007. Epub 2014 May 23.

Canonical and non-canonical Hedgehog signalling and the control of metabolism

Raffaele Teperino  1 , Fritz Aberger  2 , Harald Esterbauer  3 , Natalia Riobo  4 , John Andrew Pospisilik  5
Affiliations
Review

Canonical and non-canonical Hedgehog signalling and the control of metabolism

Raffaele Teperino et al. Semin Cell Dev Biol. 2014 Sep.

Abstract

Obesity and diabetes represent key healthcare challenges of our day, affecting upwards of one billion people worldwide. These individuals are at higher risk for cancer, stroke, blindness, heart and cardiovascular disease, and to date, have no effective long-term treatment options available. Recent and accumulating evidence has implicated the developmental morphogen Hedgehog and its downstream signalling in metabolic control. Generally thought to be quiescent in adults, Hedgehog is associated with several human cancers, and as such, has already emerged as a therapeutic target in oncology. Here, we attempt to give a comprehensive overview of the key signalling events associated with both canonical and non-canonical Hedgehog signalling, and highlight the increasingly complex regulatory modalities that appear to link Hedgehog and control metabolism. We highlight these key findings and discuss their impact for therapeutic development, cancer and metabolic disease.

Keywords: Cancer; Development; Metabolism; Non-canonical Hedgehog signalling.

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