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. 2014 Jun 23;20(26):7931-4.
doi: 10.1002/chem.201402520. Epub 2014 May 23.

Extremely fast gas/liquid reactions in flow microreactors: carboxylation of short-lived organolithiums

Aiichiro Nagaki  1 , Yusuke Takahashi, Jun-ichi Yoshida
Affiliations
Free article

Extremely fast gas/liquid reactions in flow microreactors: carboxylation of short-lived organolithiums

Aiichiro Nagaki et al. Chemistry. .
Free article

Abstract

Carboxylation of short-lived organolithiums bearing electrophilic functional groups such as nitro, cyano, and alkoxycarbonyl groups with CO2 to give carboxylic acids and active esters was accomplished in a flow microreactor system. The successful reactions indicate that gas/liquid mass transfer and the subsequent chemical reaction with CO2 are extremely fast.

Keywords: carboxylation; flow chemistry; lithiation; mass transfer; microreactors.

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