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Editorial
. 2014;13(12):1833-4.
doi: 10.4161/cc.29378. Epub 2014 May 27.

Packing for the journey: CHD5 remodels the genome

Wangzhi Li  1 , Alea A Mills  2
Affiliations
Editorial

Packing for the journey: CHD5 remodels the genome

Wangzhi Li et al. Cell Cycle. 2014.
No abstract available

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Figures

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Figure 1. Chd5 regulates chromatin remodeling in sperm. Following meiosis, haploid spermatids develop into mature sperm (upper figure). Chromatin of round spermatids (left) contains canonical histones (blue, green) that are replaced with transition proteins (triangles) and ultimately protamines (squares). Chd5 expression (brown) in round/elongating spermatids precedes histone H4 hyperacetylation (H4ac, yellow rectangle), initiating eviction of nucleosomes, resolution of DNA supercoiling, and repair by the DNA damage response pathway (crossed lightning bolt). Loss of Chd5 compromises H4ac, eviction of nucleosomes, expression of histone variants/transition proteins/protamines, repair of DNA damage, culminating in jeopardized fertility. Schematic: Jim Duffy, Cold Spring Harbor Laboratory.
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References

    1. Rousseaux S, et al. Reprod Biomed Online. 2008;16:492–503. doi: 10.1016/S1472-6483(10)60456-7. - DOI - PubMed
    1. Li W, et al. Nat Commun. 2014;5:3812. - PMC - PubMed
    1. Bergs JW, et al. PLoS One. 2014;9:e98203. doi: 10.1371/journal.pone.0098203. - DOI - PMC - PubMed
    1. Ramos L, et al. Hum Reprod. 2008;23:259–70. doi: 10.1093/humrep/dem365. - DOI - PubMed
    1. Oliva R. Hum Reprod Update. 2006;12:417–35. doi: 10.1093/humupd/dml009. - DOI - PubMed

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