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. 2014 Jul;91(1):138-45.
doi: 10.4269/ajtmh.13-0595. Epub 2014 May 27.

Clinical presentation of dengue by serotype and year of epidemic in Martinique

Laurent Thomas  1 , Fatiha Najioullah  2 , François Besnier  2 , Ruddy Valentino  2 , Raymond Césaire, Jacques Rosine, André Cabié  2 ; Working Group on Dengue
Affiliations

Clinical presentation of dengue by serotype and year of epidemic in Martinique

Laurent Thomas et al. Am J Trop Med Hyg. 2014 Jul.

Erratum in

  • Am J Trop Med Hyg. 2014 Oct;91(4):862. Césaire, Jacques Rosine Raymond [corrected to Césaire, Raymond]; [corrected to Rosine, Jacques]

Abstract

During the last decade Martinique experienced four dengue epidemics, each characterized by the predominance of 1 or 2 serotypes. In this retrospective database analysis, we investigated the relationship between dengue serotype and disease severity. Data on dengue were collected from 715 patients (male/female ratio 0.87), 14 to 91 years of age (median 35 years) examined in the adult emergency department between 2005 and 2010. In this series, DENV-4 infections more frequently had a milder clinical presentation. The DENV-2 infections were most often secondary infections admitted at the critical phase of dengue illness with signs of plasma leakage. The DENV-1 infections were disabling, particularly in females, and most often led to disease of intermediate severity, without overt plasma leakage. These data were consistent with there being differences in virulence between serotypes, regardless of the host's immune status. However, secondary DENV-2 infections showed an increased risk of plasma leakage.

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Figures

Figure 1.
Figure 1.
Number of dengue cases by serotype and year.
See this image and copyright information in PMC

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