Cross-talk between imprinted loci in Prader-Willi syndrome
- PMID: 24866188
- DOI: 10.1038/ng.2994
Cross-talk between imprinted loci in Prader-Willi syndrome
Erratum in
- Nat Genet. 2014 Jul;46(7):759
Abstract
Prader-Willi syndrome (PWS) is caused by loss of paternally expressed genes at an imprinted locus on chromosome 15, including the long noncoding RNA IPW. A new study identifies a critical role for IPW in modulating the expression of maternally expressed genes in trans, which has important implications for the understanding of imprinted gene networks.
Comment on
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The noncoding RNA IPW regulates the imprinted DLK1-DIO3 locus in an induced pluripotent stem cell model of Prader-Willi syndrome.Nat Genet. 2014 Jun;46(6):551-7. doi: 10.1038/ng.2968. Epub 2014 May 11. Nat Genet. 2014. PMID: 24816254
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