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. 2014 May;35(3):196-203.
doi: 10.11813/j.issn.0254-5853.2014.3.196.

Analysis of immunoglobulin, complements and CRP levels in serum of captive northern pig-tailed macaques (Macaca leonina)

Xiao-Liang Zhang  1 , Wei Pang  2 , De-Yao Deng  3 , Long-Bao Lv  4 , Yue Feng  5 , Yong-Tang Zheng  6
Affiliations

Analysis of immunoglobulin, complements and CRP levels in serum of captive northern pig-tailed macaques (Macaca leonina)

Xiao-Liang Zhang et al. Dongwuxue Yanjiu. 2014 May.

Abstract

The northern pig-tailed macaque (NPM，Macaca leonina) has become a widely used animal model in biomedical research. In this study, we measured serum immunoglobulin IgG, IgM, IgA, complement C3, C4 and CRP levels in 3-11 year old captive northern pig-tailed macaques using HITACHI 7600-20 automated chemistry analyzer in order to determine the influences of age and gender on these items. The results showed that serum IgA, IgM, C3 and C4 levels were not correlated with age (P>0.05), while serum IgG levels increased progressively with age (r=0.202;P=0.045). Serum IgG, IgA, IgM and C3 levels were higher in females than in males (P<0.05). Moreover, serum C3 concentration was both positively and strongly correlated with that of C4 (r=0.700; P<0.0001). This study provides basic serum immunoglobulin and complement data of captive northern pig-tailed macaques, which may prove useful for future breeding efforts and biomedical research.

Keywords: C-reactive protein; Complement; Immunoglobulin; Northern pig-tailed macaque (Macaca leonina).

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Figures

Figure 1
Figure 1
Effects of age on the levels of serum IgG, IgA, IgM, C3 and C4 in NPMs
Figure 2
Figure 2
Effects of gender on the levels of serum IgG, IgA, IgM, C3 and C4 in NPMs
Figure 3
Figure 3
Correlations of serum immunoglobulins and complements in NPMs
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