Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2014;13(12):1827-8.
doi: 10.4161/cc.29324. Epub 2014 May 27.

Megakaryocytic irreversible P-TEFb activation

Kamaleldin E Elagib  1 , Adam N Goldfarb  1
Affiliations
Editorial

Megakaryocytic irreversible P-TEFb activation

Kamaleldin E Elagib et al. Cell Cycle. 2014.
No abstract available

Keywords: 7SK snRNP; P-TEFb; calpain 2; megakaryocyte; morphogenesis.

PubMed Disclaimer

Figures

None
Figure 1. Cartoon depicting the irreversible and global P-TEFb activation pathway, leading to expression of cytoskeletal remodeling factors, suppression of proliferation, and suppression of erythroid genes expression during normal megakaryopoiesis. The pathway is disrupted by the acquired GATA1s mutation in Down syndrome patients. Germline mutations of ACTN1 and FLNA contribute to congenital macrothrombocytopenia.
See this image and copyright information in PMC

Comment on

References

    1. Liu W, et al. Cell. 2013;155:1581–95. doi: 10.1016/j.cell.2013.10.056. - DOI - PMC - PubMed
    1. Ji X, et al. Cell. 2013;153:855–68. doi: 10.1016/j.cell.2013.04.028. - DOI - PMC - PubMed
    1. Fujinaga K, et al. Nucleic Acids Res. 2012;40:9160–70. doi: 10.1093/nar/gks682. - DOI - PMC - PubMed
    1. Chen R, et al. Genes Dev. 2008;22:1356–68. doi: 10.1101/gad.1636008. - DOI - PMC - PubMed
    1. Elagib KE, et al. Dev Cell. 2013;27:607–20. doi: 10.1016/j.devcel.2013.11.013. - DOI - PMC - PubMed

MeSH terms

Substances

LinkOut - more resources