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. 2014 Sep 1;59(5):682-5.
doi: 10.1093/cid/ciu384. Epub 2014 May 27.

Etiology of severe childhood pneumonia in the Gambia, West Africa, determined by conventional and molecular microbiological analyses of lung and pleural aspirate samples

Stephen R C Howie  1 , Gerard A J Morris  1 , Rafal Tokarz  2 , Bernard E Ebruke  1 , Eunice M Machuka  1 , Readon C Ideh  1 , Osaretin Chimah  1 , Ousman Secka  1 , John Townend  1 , Michel Dione  1 , Claire Oluwalana  1 , Malick Njie  3 , Mariatou Jallow  3 , Philip C Hill  4 , Martin Antonio  1 , Brian Greenwood  5 , Thomas Briese  2 , Kim Mulholland  5 , Tumani Corrah  1 , W Ian Lipkin  2 , Richard A Adegbola  6
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Etiology of severe childhood pneumonia in the Gambia, West Africa, determined by conventional and molecular microbiological analyses of lung and pleural aspirate samples

Stephen R C Howie et al. Clin Infect Dis. .

Abstract

Molecular analyses of lung aspirates from Gambian children with severe pneumonia detected pathogens more frequently than did culture and showed a predominance of bacteria, principally Streptococcus pneumoniae, >75% being of serotypes covered by current pneumococcal conjugate vaccines. Multiple pathogens were detected frequently, notably Haemophilus influenzae (mostly nontypeable) together with S. pneumoniae.

Keywords: Gambia; children; etiology; lung aspirate; pneumonia.

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References

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