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Review
. 2013;6(4):409-13.
Epub 2013 Dec 25.

Physiopathological aspects of the subclinical alterations of thyroid function associated with acute coronary syndromes

C S Stamate  1 , A M Andronescu  1 , A C Nechita  1 , C Delcea  2 , E M Mihu  2 , M M Vintila  1
Affiliations
Review

Physiopathological aspects of the subclinical alterations of thyroid function associated with acute coronary syndromes

C S Stamate et al. J Med Life. 2013.

Abstract

The subclinical modification of thyroid function represents an important risk factor for the development of acute coronary syndromes, neglected up to this day. Knowledge of the physiopathological processes implicated in the alteration of thyroid function that induces cardiovascular dysfunction is a necessity for the understanding of the phenomena and for the finding of the adequate therapeutic solutions. While recognizing the thyroid dysfunction as a modifiable risk factor for the acute coronary syndrome, we encountered a new challenge for the clinical research regarding its implications. The ability to manage the altered thyroid homeostasis may represent a new stage of prevention at a population level for the reduction of the cardiac risk, a stage which implies a risk factor that may remain clinically mute for a long period of time if left undiagnosed, however influencing the development of the acute coronary syndromes.

Keywords: acute coronary syndrome; cardiac risk factor; subclinical thyroid dysfunction.

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References

    1. Ertugrul O, Ahmet U. Prevalence of Subclinical Hypothyroidism among Patients with Acute Myocardial Infarction. ISRN Endocrinol. 2011 - PMC - PubMed
    1. Hak AE, Pols HAP. Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the rotterdam study. Ann Intern Med. 2000;132:270–278. - PubMed
    1. Ochs N, Auer R. Meta-analysis: subclinical thyroid dysfunction and the risk for coronary heart disease and mortality. Ann Intern Med. 2008;148:832–845. - PubMed
    1. Karmisholt J, Andersen S, Laurberg P. Variation in thyroid function tests in patients with stable untreated subclinical hypothyroidism. Thyroid. 2008;18:303–308. - PubMed
    1. Yen PM. Physiological and molecular basis of thyroid hormone action. Physiol Rev. 2001;81:1097–1142. - PubMed

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