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. 2012 May;5(1):14-7.
doi: 10.14802/jmd.12004. Epub 2012 May 30.

Hypomania induced by subthalamic nucleus stimulation in a Parkinson's disease patient: does it suggest a dysfunction of the limbic circuit?

Ji Seon Kim  1 , Hee Jin Kim  2 , Ji-Young Lee  3 , Jong Min Kim  4 , Ji Young Yun  5 , Beom S Jeon  5
Affiliations

Hypomania induced by subthalamic nucleus stimulation in a Parkinson's disease patient: does it suggest a dysfunction of the limbic circuit?

Ji Seon Kim et al. J Mov Disord. 2012 May.

Abstract

The aim of this report was to describe a case of hypomania after deep brain stimulation of the subthalamic nucleus (STN DBS) in a Parkinson's disease (PD) patient. 59-year-old man with a 15-year history of PD underwent bilateral implantation of electrodes to the STN. Immediately after surgery, his motor function was markedly improved and his mood was elevated to hypomania. Fusion images of the preoperative MRI and postoperative CT scan showed that the electrodes were located in the medial portion of the STN. In this case, behavioral mood change was related to the deep brain stimulation. Moreover, the anatomical location and the functional alteration of the STN after the DBS surgery might be related to the regulatory system of the associative and limbic cortico-subcortical circuits.

Keywords: Deep brain stimulation; Hypomania; Mood; Non motor symptom; Subthalamic stimulation.

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Conflict of interest statement

The authors have no financial conflicts of interest.

Figures

Figure 1.
Figure 1.
Localization of electrode placement. The 3-dimensional location of the leads and each contact were identified on the fused images. Blue spot represents right side electrode and red spot does left. These were in the ventromedial part of the subthalamic nucleus. The stimulating contact numbers were 2 on the right side and 1 on the left.
See this image and copyright information in PMC

References

    1. Limousin P, Krack P, Pollak P, Benazzouz A, Ardouin C, Hoffmann D, et al. Electrical stimulation of the subthalamic nucleus in advanced Parkinson’s disease. N Engl J Med. 1998;339:1105–1111. - PubMed
    1. Romito LM, Scerrati M, Contarino MF, Bentivoglio AR, Tonali P, Albanese A. Long-term follow up of subthalamic nucleus stimulation in Parkinson’s disease. Neurology. 2002;58:1546–1550. - PubMed
    1. Romito LM, Raja M, Daniele A, Contarino MF, Bentivoglio AR, Barbier A, et al. Transient mania with hypersexuality after surgery for high frequency stimulation of the subthalamic nucleus in Parkinson’s disease. Mov Disord. 2002;17:1371–1374. - PubMed
    1. Appleby BS, Duggan PS, Regenberg A, Rabins PV. Psychiatric and neuropsychiatric adverse events associated with deep brain stimulation: a meta-analysis of ten years’ experience. Mov Disord. 2007;22:1722–1728. - PubMed
    1. Gervais-Bernard H, Xie-Brustolin J, Mertens P, Polo G, Klinger H, Adamec D, et al. Bilateral subthalamic nucleus stimulation in advanced Parkinson’s disease: five year follow-up. J Neurol. 2009;256:225–233. - PubMed

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