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Review
. 2014:1168:173-93.
doi: 10.1007/978-1-4939-0847-9_10.

Pathogen genome bioinformatics

Vitali Sintchenko  1 , Michael P V Roper
Affiliations
Review

Pathogen genome bioinformatics

Vitali Sintchenko et al. Methods Mol Biol. 2014.

Abstract

Recent advances in DNA sequencing technology have made the whole-genome sequencing of pathogens in a clinically relevant turn-around time both technically and economically feasible. The DNA sequencing of pathogens with epidemic potential offers new and exciting opportunities for high-resolution public health surveillance. This chapter outlines major methods and bioinformatics tools for pathogen genome characterization, the identification of infectious disease clusters, as well as for genomics-guided biosurveillance. Existing challenges are also considered.

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