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Comment
. 2014 Jul;94(4):451-3.
doi: 10.1016/j.tube.2014.04.002. Epub 2014 Apr 24.

Genetic diversity within Mycobacterium tuberculosis complex impacts on the accuracy of genotypic pyrazinamide drug-susceptibility assay

Claudio U Köser  1 , Iñaki Comas  2 , Silke Feuerriegel  3 , Stefan Niemann  3 , Sebastien Gagneux  4 , Sharon J Peacock  5
Affiliations
Comment

Genetic diversity within Mycobacterium tuberculosis complex impacts on the accuracy of genotypic pyrazinamide drug-susceptibility assay

Claudio U Köser et al. Tuberculosis (Edinb). 2014 Jul.
No abstract available

Keywords: Mycobacterium tuberculosis complex; Phylogenetic diversity; Pyrazinamide resistance.

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Figures

Figure 1
Figure 1
Whole-genome phylogeny of 219 isolates of all major MTBC lineages . Only the more phylogenetically recent lineage 3 isolates shared the pncA tcT variant at Ser65, whereas the 6 remaining lineage 3 isolates and all isolates from other lineages had the tcC variant (including the lineage 4 M. tuberculosis H37Rv laboratory strain that is used as the reference/wild-type sequence for sequence analyses). The spoligotypes for the lineage 3 isolates can be found in Supplemental Figure 1.
See this image and copyright information in PMC

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References

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