Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2014 Sep 1;67(1):71-6.
doi: 10.1097/QAI.0000000000000227.

Weight as predictors of clinical progression and treatment failure: results from the TREAT Asia Pediatric HIV Observational Database

Azar Kariminia  1 , Nicolas Durier, Gonzague Jourdain, Suneeta Saghayam, Chau V Do, Lam Van Nguyen, Rawiwan Hansudewechakul, Pagakrong Lumbiganon, Kulkanya Chokephaibulkit, Khanh Huu Truong, Virat Sirisanthana, Vibol Ung, Saphonn Vonthanak, Jintanat Ananworanich, Nik Khairulddin Nik Yusoff, Nia Kurniati, Kamarul Azahar Razali, Moy Siew Fong, Revathy Nallusamy, Dewi Kumara Wati; TREAT Asia Pediatric HIV Observational Database
Collaborators, Affiliations
Multicenter Study

Weight as predictors of clinical progression and treatment failure: results from the TREAT Asia Pediatric HIV Observational Database

Azar Kariminia et al. J Acquir Immune Defic Syndr. .

Abstract

Objective: To evaluate the value of time-updated weight and height in predicting clinical progression, and immunological and virological failure in children receiving combination antiretroviral therapy (cART).

Methods: We used Cox regression to analyze data of a cohort of Asian children.

Results: A total of 2608 children were included; median age at cART was 5.7 years. Time-updated weight for age z score < -3 was associated with mortality (P < 0.001) independent of CD4% and < -2 was associated with immunological failure (P ≤ 0.03) independent of age at cART.

Conclusions: Weight monitoring provides useful data to inform clinical management of children on cART in resource-limited settings.

PubMed Disclaimer

References

    1. WHO/UNAIDS/UNICEF . GLOBAL HIV/AIDS RESPONSE—Epidemic Update and Health Sector Progress towards Universal Access—Progress Report. World Health Organization; Geneva: [Accessed March 24, 2013]. 2011. Available at: http://www.who.int/hiv/pub/progress_report2011/en/
    1. World Health Organisation . Fact Sheet No 360. World Health Organization; Geneva: [Accessed March 24, 2013]. 2013. Geneva. Available at: http://www.who.int/mediacentre/factsheets/fs360/en/
    1. WHO/UNAIDS/UNICEF . Towards Universal Access: scaling up priority HIV/AIDS interventions in the health sector—Progress Report. World Health Organization; Geneva: [Accessed June 6, 2013]. 2007. Available at: http://www.who.int/hiv/mediacentre/universal_access_progress_report_en.pdf.
    1. Mellors JW, Munoz A, Giorgi JV, Margolick JB, Tassoni CJ, Gupta P, et al. Plasma viral load and CD4+ lymphocytes as prognostic markers of HIV-1 infection. Annals of internal medicine. 1997;126(12):946–954. - PubMed
    1. Pozniak A, Gazzard B, Anderson J, Babiker A, Churchill D, Collins S, et al. British HIV Association (BHIVA) guidelines for the treatment of HIV-infected adults with antiretroviral therapy. HIV Med. 2003;4(Suppl 1):1–41. - PubMed

Publication types

MeSH terms

Substances