Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2014 May 28;106(6):dju084.
doi: 10.1093/jnci/dju084. Print 2014 Jun.

Impact of lung cancer screening results on smoking cessation

Martin C Tammemägi  1 , Christine D Berg  2 , Thomas L Riley  2 , Christopher R Cunningham  2 , Kathryn L Taylor  2
Affiliations
Randomized Controlled Trial

Impact of lung cancer screening results on smoking cessation

Martin C Tammemägi et al. J Natl Cancer Inst. .

Abstract

Background: Lung cancer screening programs may provide opportunities to reduce smoking rates among participants. This study evaluates the impact of lung cancer screening results on smoking cessation.

Methods: Data from Lung Screening Study participants in the National Lung Screening Trial (NLST; 2002-2009) were used to prepare multivariable longitudinal regression models predicting annual smoking cessation in those who were current smokers at study entry (n = 15489, excluding those developing lung cancer in follow-up). The associations of lung cancer screening results on smoking cessation over the trial period were analyzed. All hypothesis testing used two sided P values.

Results: In adjusted analyses, smoking cessation was strongly associated with the amount of abnormality observed in the previous year's screening (P < .0001). Compared with those with a normal screen, individuals were less likely to be smokers if their previous year's screen had a major abnormality that was not suspicious for lung cancer (odds ratio [OR] = 0.811; 95% confidence interval [CI] = 0.722 to 0.912; P < .001), was suspicious for lung cancer but stable from previous screens (OR = 0.785; 95% CI = 0.706 to 0.872; P < .001), or was suspicious for lung cancer and was new or changed from the previous screen (OR = 0.663; 95% CI = 0.607 to 0.724; P < .001). Differences in smoking prevalence were present up to 5 years after the last screen.

Conclusions: Smoking cessation is statistically significantly associated with screen-detected abnormality. Integration of effective smoking cessation programs within screening programs should lead to further reduction in smoking-related morbidity and mortality.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Proportion of National Lung Screening Trial (NLST) Lung Screening Study (LSS) baseline current smokers smoking at follow-up by screening result lagged to the preceding screen. The numbers and proportions corresponding to the line points in this figure are presented in Table 2. Proportion smoking at year 1 was classified by the baseline screening result, proportion smoking at year 2 was classified by year 1 screening result, proportion smoking at years 3 through 7 were classified by the last screen result, which occurred in study year 2. LCa, lung cancer; NotLCa, not suspicious for lung cancer.
See this image and copyright information in PMC

Comment in

References

    1. Aberle DR, Adams AM, Berg CD, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. New Engl J Med. 2011;365(5):395–409 - PMC - PubMed
    1. Moyer VA. Screening for lung cancer: U.S. Preventive Services Task Force Recommendation Statement. Ann Intern Med. 2013. [published ahead of print December 31, 2013]. - PubMed
    1. Bach PB, Mirkin JN, Oliver TK, et al. Benefits and harms of CT screening for lung cancer: a systematic review. JAMA. 2012;307(22):2418–2429 - PMC - PubMed
    1. Wood DE, Eapen GA, Ettinger DS, et al. Lung cancer screening. J Natl Compr Canc Netw. 2012;10(2):240–265 - PMC - PubMed
    1. Jacobson FL, Austin JH, Field JK, et al. Development of the American Association for Thoracic Surgery guidelines for low-dose computed tomography scans to screen for lung cancer in North America: recommendations of the American Association for Thoracic Surgery Task Force for Lung Cancer Screening and Surveillance. J Thorac Cardiovasc Surg. 2012;144(1):25–32 - PubMed

Publication types

MeSH terms

Substances