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Review
. 2014:2014:751859.
doi: 10.1155/2014/751859. Epub 2014 Apr 28.

Coordinated Actions of FXR and LXR in Metabolism: From Pathogenesis to Pharmacological Targets for Type 2 Diabetes

Lin Ding  1 , Shuguang Pang  1 , Yongmei Sun  1 , Yuling Tian  1 , Li Yu  1 , Ningning Dang  1
Affiliations
Review

Coordinated Actions of FXR and LXR in Metabolism: From Pathogenesis to Pharmacological Targets for Type 2 Diabetes

Lin Ding et al. Int J Endocrinol. 2014.

Abstract

Type 2 diabetes (T2D) is the most prevalent metabolic disease, and many people are suffering from its complications driven by hyperglycaemia and dyslipidaemia. Nuclear receptors (NRs) are ligand-inducible transcription factors that mediate changes to metabolic pathways within the body. As metabolic regulators, the farnesoid X receptor (FXR) and the liver X receptor (LXR) play key roles in the pathogenesis of T2D, which remains to be clarified in detail. Here we review the recent progress concerning the physiological and pathophysiological roles of FXRs and LXRs in the regulation of bile acid, lipid and glucose metabolism and the implications in T2D, taking into account that these two nuclear receptors are potential pharmaceutical targets for the treatment of T2D and its complications.

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Figures

Figure 1
Figure 1
FXR and LXR target genes in bile acids, lipid, and glucose metabolism.
See this image and copyright information in PMC

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