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Review
. 2014 Jun;41(2):331-45.
doi: 10.1016/j.clp.2014.02.006.

Complications associated with parenteral nutrition in the neonate

Kara L Calkins  1 , Robert S Venick  2 , Sherin U Devaskar  3
Affiliations
Review

Complications associated with parenteral nutrition in the neonate

Kara L Calkins et al. Clin Perinatol. 2014 Jun.

Abstract

Although parenteral nutrition (PN) is life-sustaining, it is associated with many complications including parenteral nutrition-associated liver disease (PNALD) and central line-associated bloodstream infections (CLASBIs), which carry a high morbidity and mortality and impose a burden on the health care system. Evidence has emerged that the dose and composition of intravenous lipid products may alter the incidence of PNALD. However, other patient and PN-related factors, such as prematurity, birth weight, and gastrointestinal anatomy and function, are important. To improve neonatal care, future research on optimizing the content of PN and decreasing the incidence IFALD and CLASBIs is required.

Keywords: Infections; Lipids; Neonates; Parenteral nutrition; Parenteral nutrition–associated liver disease.

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Figures

Figure 1
Figure 1
Common complications and benefits associated with parenteral nutrition (PN). PNALD, parenteral nutrition-associated liver disease (PNALD). CLASBIs, central line-associated bloodstream infections.
Figure 2
Figure 2
Omega-3 and omega-6 fatty acids and their functions.
Figure 3
Figure 3
Proposed etiology of parenteral nutrition-associated liver disease.
See this image and copyright information in PMC

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