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Review
. 2014 Jun;41(2):451-61.
doi: 10.1016/j.clp.2014.02.012. Epub 2014 Apr 13.

LCPUFAs as conditionally essential nutrients for very low birth weight and low birth weight infants: metabolic, functional, and clinical outcomes-how much is enough?

Maria Makrides  1 , Ricardo Uauy  2
Affiliations
Review

LCPUFAs as conditionally essential nutrients for very low birth weight and low birth weight infants: metabolic, functional, and clinical outcomes-how much is enough?

Maria Makrides et al. Clin Perinatol. 2014 Jun.

Abstract

Preterm infants are denied the rapid accumulation of docosahexaenoic acid (DHA) occurring during the third trimester in utero. The potential benefit of long-chain polyunsaturated fatty acids (LCPUFAs) has generated interest over the last 3 decades. Early intervention trials assessed the effects of supplementing infant formulas lacking DHA with concentrations equivalent to LCPUFA in milk of women from Westernized societies, leading to the inclusion of LCPUFA by the year 2000. Recently attention has been on determining the optimal dose of DHA and on whether there is in advantage in matching the higher doses of late pregnancy.

Keywords: Development; LCPUFA; Low birth weight infants; Preterm; Randomized controlled trials; Very low birth weight infants.

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