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. 1989 Jan;4(1):48-53.
doi: 10.3904/kjim.1989.4.1.48.

Fibrinolytic response to standardized venous occlusion in different age groups

S Y Hong, S J Pyo, M H Kim, S K Kim, I S Park, D Y Oh, S J Kim

Fibrinolytic response to standardized venous occlusion in different age groups

S Y Hong et al. Korean J Intern Med. 1989 Jan.

Abstract

The purpose of this study was to find out the range and distribution of fibrinolytic response to standardized venous occlusion in healthy volunteers and to determine whether there were any differences according to age and sex. In 118 healthy volunteers (55 males, 63 females) of various age groups, the total fibrinolytic activity in euglobulin fractions was measured by a well controlled fibrin plate method before and after venous occlusion of 5 minutes at 100 mmHg. The difference between our method and previous methods is that we occluded for a relatively shorter duration than that of previous studies (15-20 minutes) at constant pressure (100 mmHg), instead of midway between systolic and diastolic pressure. This method was reliable and reproducible as a tool to qualify and assess the fibrinolytic activity capacity of individuals. The results showed that there was no difference in basal fibrinolytic activity and the response to stimuli in various age groups (p greater than 0.25) and in male and female groups (0.1 less than p less than 0.375).

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Figures

Fig. 1
Fig. 1
Fibrinolytic activity of 5 consecutive studies on a 41-year-old male volunteer. Consecutive studies were performed every 2 or 3 days from the left cubital vein.
Fig. 2
Fig. 2
Fibrinolytic activity in various age groups. Bars indicate mean + SD. There was no difference in basal and stimulated fibrinolytic activity between the various age groups.
Fig. 3
Fig. 3
Fibrinolytic activity of males (Fig. 3-A) and females (Fig. 3-B) in various age groups. Bars indicate mean + SD. There was no difference in basal and stimulated fibrinolytic activity between the various age groups in both males and females.
Fig. 4
Fig. 4
Comparison of fibrinolytic activity between males and females. Bars indicate mean + SD. There was no sexual difference in basal fibrinolytic activity and the increment after stimulation.
Fig. 5
Fig. 5
Correlation between age and basal fibrinolytic activity (Fig. 5 A) and the increment after stimulation (Figure 5 B).
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