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. 2014 Oct;34(10):750-3.
doi: 10.1038/jp.2014.102. Epub 2014 May 29.

The utilization of circulating cell-free fetal DNA testing and decrease in invasive diagnostic procedures: an institutional experience

K E Pettit  1 , A D Hull  1 , L Korty  1 , M C Jones  1 , D H Pretorius  1
Affiliations

The utilization of circulating cell-free fetal DNA testing and decrease in invasive diagnostic procedures: an institutional experience

K E Pettit et al. J Perinatol. 2014 Oct.

Abstract

Objective: To characterize the patient population utilizing circulating cell-free fetal DNA (ccffDNA) testing at a large academic center and evaluate trends in the performance of invasive diagnostic procedures.

Study design: A retrospective cohort study of all patients who underwent cell-free DNA testing from May to December 2012 was performed.

Result: During the study period, 206 patients had cell-free DNA testing. Of those, 75% (155/206) were of ages ⩾ 35 years. Of those undergoing ccffDNA testing, 41% had positive aneuploidy screening and 38% had abnormal ultrasound findings. Only 7% of the patients with negative ccffDNA testing opted for an invasive diagnostic procedure compared with 60% with positive testing (P<0.01). The rate of invasive procedures decreased from 5.9% of all visits to the center during a similar 8-month period in 2010 to 4.1% of all visits during the study period (P<0.01).

Conclusion: Our data suggest that ccffDNA testing leads to reduced uptake of invasive procedures.

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