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Review
. 2014 Jun;16(6):488-94.
doi: 10.1038/ncb2976.

Oncogenic roles of EMT-inducing transcription factors

Alain Puisieux  1 , Thomas Brabletz  2 , Julie Caramel  1
Affiliations
Review

Oncogenic roles of EMT-inducing transcription factors

Alain Puisieux et al. Nat Cell Biol. 2014 Jun.

Abstract

The plasticity of cancer cells underlies their capacity to adapt to the selective pressures they encounter during tumour development. Aberrant reactivation of epithelial-mesenchymal transition (EMT), an essential embryonic process, can promote cancer cell plasticity and fuel both tumour initiation and metastatic spread. Here we discuss the roles of EMT-inducing transcription factors in creating a pro-tumorigenic setting characterized by an intrinsic ability to withstand oncogenic insults through the mitigation of p53-dependent oncosuppressive functions and the gain of stemness-related properties.

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References

    1. Nat Rev Cancer. 2005 Jun;5(6):481-8 - PubMed
    1. Cancer Res. 2013 Apr 1;73(7):2059-69 - PubMed
    1. Cell Stem Cell. 2010 Jan 8;6(1):59-70 - PubMed
    1. Nat Med. 2011 Aug 07;17(9):1101-8 - PubMed
    1. Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5402-7 - PubMed

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