Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Mar;8(2):346-349.
doi: 10.1177/1932296813519012. Epub 2014 Feb 18.

Negative Pressure Wound Therapy With Low Pressure and Gauze Dressings to Treat Diabetic Foot Wounds

Lawrence A Lavery  1 , Douglas P Murdoch  2 , Paul J Kim  3 , Javier La Fontaine  4 , Gaurav Thakral  4 , Kathryn E Davis  4
Affiliations

Negative Pressure Wound Therapy With Low Pressure and Gauze Dressings to Treat Diabetic Foot Wounds

Lawrence A Lavery et al. J Diabetes Sci Technol. 2014 Mar.

Abstract

This study was a prospective cohort study to evaluate negative pressure wound therapy (NPWT) with low pressure and a gauze dressing to treat diabetic foot wounds. Thirty patients with diabetic foot wounds were consented to a prospective study to evaluate wound closure and complications to evaluate NPWT with low pressure (80 mmHg) and a gauze dressing interface (EZCare, Smith and Nephew) for up to 5 weeks. NPWT was changed 3 times a week. Study subjects were evaluated once a week for adverse events and wound measurements. Of study subjects, 43% attained at least a 50% wound area reduction after 4 weeks of therapy. Our results suggest that a high rate of wound closure could be expected with low pressure and a gauze interface.

Keywords: amputation; diabetes; infection; negative pressure; ulceration.

PubMed Disclaimer

Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: LAL has research funding from Smith and Nephew, KCI, Innovative Therapies Inc, Convatec and Thermoteck; is on the Scientific Advisory Board of Innovative Therapies Inc; and is part of the Speaker’s Bureau of Smith and Nephew. DPM has research funding from Smith and Nephew. PJK has research funding from KCI. JL has research funding from Smith and Nephew, KCI, Innovative Therapies Inc, and Convatec and is part of the Speaker’s Bureau of Shire and Smith and Nephew. KED has research funding from Innovative Therapies Inc, Convatec, and Thermoteck.

Figures

Figure 1.
Figure 1.
Wound size and wound volume for all study subjects.
Figure 2.
Figure 2.
Percentage wound area reduction and percentage wound volume reduction compared to baseline for all subjects.
Figure 3.
Figure 3.
Percentage wound area reduction and percentage wound volume reduction compared to baseline for responders and nonresponders. Responders were defined as patients who achieved at least a 50% wound area reduction in 4 weeks. Nonresponders had <50% wound area reduction. Of study subjects, 43% achieved at least a 50% wound area reduction. There was a significant difference between responders and nonresponders in weeks 3 and 5. *P = .01.
See this image and copyright information in PMC

References

    1. Armstrong DG, Lavery LA. Negative pressure wound therapy after partial diabetic foot amputation: a multicentre, randomised controlled trial. Lancet. 2005;366(9498):1704-10. - PubMed
    1. Blume PA, Walters J, Payne W, Ayala J, Lantis J. Comparison of negative pressure wound therapy using vacuum-assisted closure with advanced moist wound therapy in the treatment of diabetic foot ulcers: a multicenter randomized controlled trial. Diabetes Care. 2008;31(4):631-636. - PubMed
    1. Borgquist O, Ingemansson R, Malmsjo M. The influence of low and high pressure levels during negative-pressure wound therapy on wound contraction and fluid evacuation. Plast Reconstr Surg. 2011;127(2):551-559. - PubMed
    1. Borgquist O, Ingemansson R, Malmsjo M. Wound edge microvascular blood flow during negative-pressure wound therapy: examining the effects of pressures from −10 to −175 mmHg. Plast Reconstr Surg. 2010;125(2):502-509. - PubMed
    1. Borgquist O, Gustafsson L, Ingemansson R, Malmsjo M. Micro- and macromechanical effects on the wound bed of negative pressure wound therapy using gauze and foam. Ann Plast Surg. 2010;64(6):789-793. - PubMed