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Meta-Analysis
. 2014 May 28;20(20):6345-52.
doi: 10.3748/wjg.v20.i20.6345.

No association of G-protein beta polypeptide 3 polymorphism with irritable bowel syndrome: evidence from a meta-analysis

Zhi-Gang Pan  1 , Chen Xiao  1 , Dong-Xing Su  1
Affiliations
Meta-Analysis

No association of G-protein beta polypeptide 3 polymorphism with irritable bowel syndrome: evidence from a meta-analysis

Zhi-Gang Pan et al. World J Gastroenterol. .

Abstract

Aim: To clarify the associations between G-protein beta polypeptide 3 (GNB3) C825T polymorphism and risk of the irritable bowel syndrome (IBS) by a meta-analysis.

Methods: We searched relevant studies in PubMed, EMBASE, CNKI, Google Scholar, Ovid and Cochrane library prior to October 2013. The strengths of the associations between GNB3 C825T polymorphism and IBS risk were estimated by odds ratios (ORs) with 95% confidence interval (CIs).

Results: We identified seven case-control studies with 1085 IBS cases and 1695 controls for the analysis. We found no significantly associations of GNB3 C825T polymorphism with IBS risk in the overall population (CC vs TT, OR = 1.12, 95%CI: 0.86-1.45; CC + CT vs TT, OR = 1.17, 95%CI: 0.92-1.49; TT + CT vs CC, OR = 0.93, 95%CI: 0.80-1.08; C vs T, OR = 1.08, 95%CI: 0.97-1.21). Subgroup analysis did not reveal significant associations either in Asian population or Caucasian population. The pooled results of four studies fail to show associations of GNB3 C825T polymorphism with subtypes of IBS (constipation-dominant type, diarrhea-dominant type and mixed type).

Conclusion: The present study suggests no associations of GNB3 C825T polymorphism with IBS risk.

Keywords: G-protein beta polypeptide 3; Irritable bowel syndrome; Meta-analysis; Polymorphisms.

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Figures

Figure 1
Figure 1
Forest plot of the associations between GNB3 C825T polymorphism and irritable bowel syndrome risk under four models. (CC vs TT; CC + CT vs TT; TT + CT vs CC; C vs T).
Figure 2
Figure 2
Forest plot of the associations between GNB3 C825T polymorphism and irritable bowel syndrome subtype risk under four models. A: Associations with IBS-C; B: Associations with IBS-D; C: Associations with IBS-M. IBS: Irritable bowel syndrome.
See this image and copyright information in PMC

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References

    1. Drossman DA, Morris CB, Hu Y, Toner BB, Diamant N, Leserman J, Shetzline M, Dalton C, Bangdiwala SI. A prospective assessment of bowel habit in irritable bowel syndrome in women: defining an alternator. Gastroenterology. 2005;128:580–589. - PubMed
    1. van Tilburg MA, Whitehead WE. New paradigm for studying genetic contributions to irritable bowel syndrome. Dig Dis Sci. 2012;57:2484–2486. - PMC - PubMed
    1. Locke GR, Zinsmeister AR, Talley NJ, Fett SL, Melton LJ. Familial association in adults with functional gastrointestinal disorders. Mayo Clin Proc. 2000;75:907–912. - PubMed
    1. Bengtson MB, Rønning T, Vatn MH, Harris JR. Irritable bowel syndrome in twins: genes and environment. Gut. 2006;55:1754–1759. - PMC - PubMed
    1. Lee HJ, Lee SY, Choi JE, Kim JH, Sung IK, Park HS, Jin CJ. G protein beta3 subunit, interleukin-10, and tumor necrosis factor-alpha gene polymorphisms in Koreans with irritable bowel syndrome. Neurogastroenterol Motil. 2010;22:758–763. - PubMed

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