Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014:2014:679754.
doi: 10.1155/2014/679754. Epub 2014 May 4.

Oxidative stress and inflammation in diabetic complications

Ajit Vikram  1 , Durga Nand Tripathi  2 , Ashutosh Kumar  3 , Sandeep Singh  4
Affiliations

Oxidative stress and inflammation in diabetic complications

Ajit Vikram et al. Int J Endocrinol. 2014.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Life-style and genetic factors contribute to the development of oxidative stress and mild systemic inflammation resulting in decreased insulin-sensitivity which is accompanied by compensatory hyperinsulinemia and mild hyperglycemia, a prediabetic state. As β-cells fail to meet increased demand for insulin, frank diabetes develops with subnormal level of insulin and even higher glucose level. Hyperinsulinaemic condition in prediabetic state and profound dysregulation of glucose and lipid metabolism in diabetic condition further aggravate oxidative stress and inflammation. All these factors contribute to the development of diabetes associated complications.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Harcourt BE, Penfold SA, Forbes JM. Coming full circle in diabetes mellitus: from complications to initiation. Nature Reviews Endocrinology. 2013;9(2):113–123. - PubMed
    1. Malek M, Aghili R, Emami Z, Khamseh ME. Risk of cancer in diabetes: the effect of metformin. ISRN Endocrinology. 2013;2013:9 pages.636927 - PMC - PubMed
    1. Vikram A, Jena G, Ramarao P. Insulin-resistance and benign prostatic hyperplasia: the connection. European Journal of Pharmacology. 2010;641(2-3):75–81. - PubMed
    1. Jiang ZY, Lin YW, Clemont A, et al. Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. Journal of Clinical Investigation. 1999;104(4):447–457. - PMC - PubMed

LinkOut - more resources