Assessing function and endurance in adults with spinal and bulbar muscular atrophy: validity of the adult myopathy assessment tool

Affiliations

¹ Research Service/Geriatrics and Extended Care, Washington, DC Veterans Affairs Medical Center, 50 Irving Street, NW, Room 11G, Washington, DC 20422, USA ; School of Public Health and Health Services, George Washington University, 2033 K Street, NW, Suite 210, Washington, DC 20006, USA ; Rehabilitation Medicine Department, Clinical Center, Department of Health and Human Services (DHHS), National Institutes of Health (NIH), 10 Center Drive, Bethesda, MD 20892, USA.
² National Institute of Neurological Disorders and Stroke (NINDS), Neurogenetics Branch, Department of Health and Human Services (DHHS), National Institutes of Health (NIH), Building 35, Room 2A-1000, 35 Convent Drive, MSC 3705, Bethesda, MD 20892, USA ; Department of Epidemiology, University of North Carolina at Chapel Hill Gillings, School of Global Public Health, 170 Rosenau Hall, Campus Box 7400, 135 Dauer Drive, Chapel Hill, NC 27599, USA.
³ Rehabilitation Medicine Department, Clinical Center, Department of Health and Human Services (DHHS), National Institutes of Health (NIH), 10 Center Drive, Bethesda, MD 20892, USA.
⁴ National Institute of Neurological Disorders and Stroke (NINDS), Neurogenetics Branch, Department of Health and Human Services (DHHS), National Institutes of Health (NIH), Building 35, Room 2A-1000, 35 Convent Drive, MSC 3705, Bethesda, MD 20892, USA.
⁵ National Institute of Neurological Disorders and Stroke (NINDS), Neurogenetics Branch, Department of Health and Human Services (DHHS), National Institutes of Health (NIH), Building 35, Room 2A-1000, 35 Convent Drive, MSC 3705, Bethesda, MD 20892, USA ; Center for Patient Care and Outcomes Research, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
⁶ Clinical Neurosciences Program, NINDS, NIH, 10 Center Drive, Room 5N230, Bethesda, MD 20814, USA.
⁷ National Institute of Neurological Disorders and Stroke (NINDS), Neurogenetics Branch, Department of Health and Human Services (DHHS), National Institutes of Health (NIH), Building 35, Room 2A-1000, 35 Convent Drive, MSC 3705, Bethesda, MD 20892, USA ; Neurology Department, University of Maryland, 110 South Paca Street, Baltimore, MD 21201, USA.
⁸ Rehabilitation Medicine Department, Clinical Center, Department of Health and Human Services (DHHS), National Institutes of Health (NIH), 10 Center Drive, Bethesda, MD 20892, USA ; Physical Medicine and Rehabilitation Service, Veterans Affairs Medical Center, 650 East Indian School Road, Phoenix AZ 85012, USA.
⁹ Department of Physical Therapy, Thomas J. Long School of Pharmacy & Health Sciences, University of the Pacific, 3601 Pacific Avenue, Stockton, CA 95211, USA.

PMID: 24876969
PMCID: PMC4026974
DOI: 10.1155/2014/873872

Assessing function and endurance in adults with spinal and bulbar muscular atrophy: validity of the adult myopathy assessment tool

Michael O Harris-Love et al. Rehabil Res Pract. 2014.

. 2014:2014:873872.

doi: 10.1155/2014/873872. Epub 2014 May 5.

Affiliations

¹ Research Service/Geriatrics and Extended Care, Washington, DC Veterans Affairs Medical Center, 50 Irving Street, NW, Room 11G, Washington, DC 20422, USA ; School of Public Health and Health Services, George Washington University, 2033 K Street, NW, Suite 210, Washington, DC 20006, USA ; Rehabilitation Medicine Department, Clinical Center, Department of Health and Human Services (DHHS), National Institutes of Health (NIH), 10 Center Drive, Bethesda, MD 20892, USA.
² National Institute of Neurological Disorders and Stroke (NINDS), Neurogenetics Branch, Department of Health and Human Services (DHHS), National Institutes of Health (NIH), Building 35, Room 2A-1000, 35 Convent Drive, MSC 3705, Bethesda, MD 20892, USA ; Department of Epidemiology, University of North Carolina at Chapel Hill Gillings, School of Global Public Health, 170 Rosenau Hall, Campus Box 7400, 135 Dauer Drive, Chapel Hill, NC 27599, USA.
³ Rehabilitation Medicine Department, Clinical Center, Department of Health and Human Services (DHHS), National Institutes of Health (NIH), 10 Center Drive, Bethesda, MD 20892, USA.
⁴ National Institute of Neurological Disorders and Stroke (NINDS), Neurogenetics Branch, Department of Health and Human Services (DHHS), National Institutes of Health (NIH), Building 35, Room 2A-1000, 35 Convent Drive, MSC 3705, Bethesda, MD 20892, USA.
⁵ National Institute of Neurological Disorders and Stroke (NINDS), Neurogenetics Branch, Department of Health and Human Services (DHHS), National Institutes of Health (NIH), Building 35, Room 2A-1000, 35 Convent Drive, MSC 3705, Bethesda, MD 20892, USA ; Center for Patient Care and Outcomes Research, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
⁶ Clinical Neurosciences Program, NINDS, NIH, 10 Center Drive, Room 5N230, Bethesda, MD 20814, USA.
⁷ National Institute of Neurological Disorders and Stroke (NINDS), Neurogenetics Branch, Department of Health and Human Services (DHHS), National Institutes of Health (NIH), Building 35, Room 2A-1000, 35 Convent Drive, MSC 3705, Bethesda, MD 20892, USA ; Neurology Department, University of Maryland, 110 South Paca Street, Baltimore, MD 21201, USA.
⁸ Rehabilitation Medicine Department, Clinical Center, Department of Health and Human Services (DHHS), National Institutes of Health (NIH), 10 Center Drive, Bethesda, MD 20892, USA ; Physical Medicine and Rehabilitation Service, Veterans Affairs Medical Center, 650 East Indian School Road, Phoenix AZ 85012, USA.
⁹ Department of Physical Therapy, Thomas J. Long School of Pharmacy & Health Sciences, University of the Pacific, 3601 Pacific Avenue, Stockton, CA 95211, USA.

PMID: 24876969
PMCID: PMC4026974
DOI: 10.1155/2014/873872

Abstract

Purpose. The adult myopathy assessment tool (AMAT) is a performance-based battery comprised of functional and endurance subscales that can be completed in approximately 30 minutes without the use of specialized equipment. The purpose of this study was to determine the construct validity and internal consistency of the AMAT with a sample of adults with spinal and bulbar muscular atrophy (SBMA). Methods. AMAT validity was assessed in 56-male participants with genetically confirmed SBMA (mean age, 53 ± 10 years). The participants completed the AMAT and assessments for disease status, strength, and functional status. Results. Lower AMAT scores were associated with longer disease duration (r = -0.29; P < 0.03) and lower serum androgen levels (r = 0.49-0.59; P < 0.001). The AMAT was significantly correlated with strength and functional status (r = 0.82-0.88; P < 0.001). The domains of the AMAT exhibited good internal consistency (Cronbach's α = 0.77-0.89; P < 0.001). Conclusions. The AMAT is a standardized, performance-based tool that may be used to assess functional limitations and muscle endurance. The AMAT has good internal consistency, and the construct validity of the AMAT is supported by its significant associations with hormonal, strength, and functional characteristics of adults with SBMA. This trial is registered with Clinicaltrials.gov identifier NCT00303446.

PubMed Disclaimer

Figures

**Figure 1**
Isometric maximal voluntary contraction testing via the quantitative muscle assessment device. (Participant positioning shown for the: (a) hip extensors and (b) elbow flexors.)

See this image and copyright information in PMC

References

1. Mänty M, de Leon CF, Rantanen T, et al. Mobility-related fatigue, walking speed, and muscle strength in older people. The Journals of Gerontology A, Biological Sciences and Medical Sciences. 2012;67(5):523–529. - PubMed
1. Rantanen T, Guralnik JM, Leveille S, et al. Racial differences in muscle strength in disabled older women. Journals of Gerontology A, Biological Sciences and Medical Sciences. 1998;53(5):B355–B361. - PubMed
1. Rantanen T. Muscle strength, disability and mortality. Scandinavian Journal of Medicine and Science in Sports. 2003;13(1):3–8. - PubMed
1. Lowes LP, Alfano L, Viollet L, et al. Knee extensor strength exhibits potential to predict function in sporadic inclusion-body myositis. Muscle and Nerve. 2012;45(2):163–168. - PMC - PubMed
1. Jacobson BH, Smith D, Fronterhouse J, Kline C, Boolani A. Assessment of the benefit of powered exercises for muscular endurance and functional capacity in elderly participants. Journal of Physical Activity & Health. 2012;9(7):1030–1035. - PubMed

Associated data

Actions
- Search in PubMed
- Search in ClinicalTrials.gov

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Medical
- ClinicalTrials.gov

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Assessing function and endurance in adults with spinal and bulbar muscular atrophy: validity of the adult myopathy assessment tool

Affiliations

Assessing function and endurance in adults with spinal and bulbar muscular atrophy: validity of the adult myopathy assessment tool

Authors

Affiliations

Abstract

Figures

References

Associated data

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical