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Clinical Trial
. 2014:2014:565080.
doi: 10.1155/2014/565080. Epub 2014 May 4.

Serum C-reactive protein and procalcitonin kinetics in patients undergoing elective total hip arthroplasty

Affiliations
Clinical Trial

Serum C-reactive protein and procalcitonin kinetics in patients undergoing elective total hip arthroplasty

Sandra Battistelli et al. Biomed Res Int. 2014.

Abstract

Background: The sensitivity and the specificity of different methods to detect periprosthetic infection have been questioned. The current study aimed to investigate the kinetics of C-reactive protein (CRP) and procalcitonin (PCT) in patients undergoing uncomplicated elective total hip arthroplasty (THA), to provide a better interpretation of their levels in noninfectious inflammatory reaction.

Methods: A total of 51 patients were included. Serum CRP and PCT concentrations were obtained before surgery, on the 1st, 3rd, and 7th postoperative days and after discharge on the 14th and 30th days and at 2 years.

Results: Both markers were confirmed to increase after surgery. The serum CRP showed a marked increase on the 3rd postoperative day while the peak of serum PCT was earlier, even if much lower, on the first day. Then, they declined slowly approaching the baseline values by the second postoperative week. PCT mean values never exceed concentrations typically related to bacterial infections.

Conclusions: CRP is very sensitive to inflammation. It could be the routine screening test in the follow-up of THA orthopaedic patients, but it should be complemented by PCT when there is the clinical suspicion of periprosthetic infection.

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Figures

Figure 1
Figure 1
Mean postoperative PCT and CRP levels in patients after hip surgery. The horizontal axis represents postoperative days and the vertical axis represents the respective concentration of PCT and CRP. *P value significantly different from baseline.

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References

    1. Pulido L, Ghanem E, Joshi A, Purtill JJ, Parvizi J. Periprosthetic joint infection: the incidence, timing, and predisposing factors. Clinical Orthopaedics and Related Research. 2008;466(7):1710–1715. - PMC - PubMed
    1. Choong PFM, Dowsey MM, Carr D, Daffy J, Stanley P. Risk factors associated with acute hip prosthetic joint infections and outcome of treatment with a rifampinbased regimen. Acta Orthopaedica. 2007;78(6):755–765. - PubMed
    1. Phillips JE, Crane TP, Noy M, Elliott TSJ, Grimer RJ. The incidence of deep prosthetic infections in a specialist orthopaedic hospital. A 15-year prospective survey. Journal of Bone and Joint Surgery B. 2006;88(7):943–948. - PubMed
    1. Ridker PM. High-sensitivity C-reactive protein: potential adjunct for global risk assessment in the primary prevention of cardiovascular disease. Circulation. 2001;103(13):1813–1818. - PubMed
    1. Tsimikas S, Willerson JT, Ridker PM. C-reactive protein and other emerging blood biomarkers to optimize risk stratification of vulnerable patients. Journal of the American College of Cardiology. 2006;47(8):C19–C31. - PubMed

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