Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jan;143(2):225-41.
doi: 10.1017/S0950268814001356. Epub 2014 May 30.

Worldwide incidence of cervical lesions: a systematic review

J Ting  1 , A F Rositch  2 , S M Taylor  3 , L Rahangdale  4 , H M Soeters  5 , X Sun  5 , J S Smith  5
Affiliations

Worldwide incidence of cervical lesions: a systematic review

J Ting et al. Epidemiol Infect. 2015 Jan.

Abstract

We conducted a systematic review summarizing data on incidence of high- and low-grade lesions in women with normal baseline cervical cytology, stratified by age (<30 and ⩾30 years), and baseline human papillomavirus (HPV) infection. Incidence of high- and low-grade lesions in women aged ⩾30 years with a baseline HPV infection increased over follow-up time (5-127 months), although incidence generally remained <10%. Without baseline HPV infection, incidence of high-grade lesions remained low over follow-up time (<5% over 5-122 months). Incidence of high-grade lesions in women aged ⩾30 years with baseline HPV infection appeared similar to that in women aged <30 years. In some women aged <30 years, high-grade lesions can develop relatively shortly after initial HPV infection. We observed an increase in low-grade lesions over time in women aged ⩾30 years with baseline HPV infection, potentially indicative of an HPV infection that is potentially progressing to higher grade lesions.

PubMed Disclaimer

Conflict of interest statement

Jennifer S. Smith has received research grants, served on advisory boards, and/or been a speaker for GlaxoSmithKline, Merck Corporation, Hologic Gen-Probe, Qiagen, and BD Diagnostics. Sylvia M. Taylor is an employee of GlaxoSmithKline.

Figures

Fig. 1.
Fig. 1.
Normal baseline cervical cytology to HSIL/CIN2/3 by age and HPV infection at baseline. CIN, Cervical intraepithelial neoplasia; HPV, human papillomavirus; mixed HPV, studies that include both HPV-positive and HPV-negative women; HSIL, high-grade squamous intraepithelial lesions.
Fig. 2.
Fig. 2.
Normal baseline cervical cytology to incident LSIL/CIN 1 by age and HPV infection at baseline. CIN, Cervical intraepithelial neoplasia; HPV, human papillomavirus; mixed HPV, studies that include both HPV-positive and HPV-negative women; LSIL, low-grade squamous intraepithelial lesions.
See this image and copyright information in PMC

References

    1. Walboomers JM, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. Journal of Pathology 1999; 89: 12–19. - PubMed
    1. Smith JS, et al. Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: a meta-analysis update. International Journal of Cancer 2007; 121: 621–132. - PubMed
    1. Moscicki A, et al. Updating the natural history of HPV and anogenital cancer. Vaccine 2006; 24: S42–51. - PubMed
    1. Cuzick J, et al. Overview of the European and North American studies on HPV testing in primary cervical cancer screening. International Journal of Cancer 2006; 119: 1095–1101. - PubMed
    1. Saslow D, et al. American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. American Journal of Clinical Pathology 2012; 137: 516–542. - PubMed

Publication types