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Review
. 2015 Feb;1849(2):201-9.
doi: 10.1016/j.bbagrm.2014.05.022. Epub 2014 May 27.

COUP-TFs and eye development

Ke Tang  1 , Sophia Y Tsai  2 , Ming-Jer Tsai  3
Affiliations
Review

COUP-TFs and eye development

Ke Tang et al. Biochim Biophys Acta. 2015 Feb.

Abstract

Recent studies reveal that COUP-TF genes are essential for neural development, cardiovascular development, energy metabolism and adipogenesis, as well as for organogenesis of multiple systems. In this review, we mainly describe the COUP-TF genes, molecular mechanisms of COUP-TF action, and their crucial functions in the morphogenesis of the murine eye. Mutations of COUP-TF genes lead to the congenital coloboma and/or optic atrophy in both mouse and human, indicating that the study on COUP-TFs and the eye will benefit our understanding of the etiology of human ocular diseases. This article is part of a Special Issue entitled: Nuclear receptors in animal development.

Keywords: COUP-TFI; COUP-TFII; Development; Eye.

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Figures

Fig. 1
Fig. 1
Molecular mechanisms of COUP-TF action. (top panel) COUP-TFs repress gene expression by directly binding to the DR (direct repeat) site of the gene, such as Pax6 in the eye [19], etc. (Table 1). (Bottom panel) COUP-TFs activate gene expression through forming a modulatory complex with the Sp1 transcription factor, which binds at the Sp1 site of the gene, such as Otx2 in the eye [19], etc. (Table 2).
Fig. 2
Fig. 2
COUP-TF genes and eye development. (A) The expression of COUP-TFs and other key regulators in four domains of the early optic vesicle. Along the dorso-distal and ventro-proximal axis of the early optic vesicle, COUP-TFs are expressed highest in the pdOS, highly in the pRPE, and relatively low in the ventral pNR and pvOS. (B) COUP-TFs are necessary for the differentiation of dOS. (C) COUP-TFs are crucial determinants for the RPE identity. (D) COUP-TFs and the formation of the NR-vOS boundary. dOS, dorsal optic stalk; NR, neural retina; pdOS, presumptive dorsal optic stalk; pNR, presumptive neural retina; pRPE, presumptive retinal pigmented epithelium; pvOS, presumptive ventral optic stalk; vOS, ventral optica stalk.
See this image and copyright information in PMC

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