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. 2014 Jun;19(3):175-181.
doi: 10.1177/1358863X14532705. Epub 2014 May 30.

ICAM-1 and SRD5A1 gene polymorphisms in symptomatic peripheral artery disease

Vincenza Barresi  1 , Salvatore S Signorelli  2 , Nicolò Musso  1 , Massimiliano Anzaldi  2 , Valerio Fiore  2 , Mario Alberghina  3 , Daniele Filippo Condorelli  4
Affiliations

ICAM-1 and SRD5A1 gene polymorphisms in symptomatic peripheral artery disease

Vincenza Barresi et al. Vasc Med. 2014 Jun.

Abstract

The genotype distribution of two gene polymorphisms, previously associated with peripheral artery disease (PAD), has been evaluated in a population of diabetic (DPAD) and non-diabetic (NDPAD) patients affected by symptomatic PAD (stages II-IV). A decreased frequency of the AA genotype of rs5498 (ICAM-1) was observed in the PAD subjects compared to controls but this result did not reach statistical significance (p=0.06 by chi-squared test). On the contrary, a significant increase in the frequency of the GG homozygous genotype of rs248793 (SRD5A1) was observed in the PAD patient group in comparison to controls (p=0.01). These data confirm that the GG genotype of rs248793 in the SRD5A1 gene is significantly associated with symptomatic PAD and show a trend towards a stronger association with the non-diabetic status.

Keywords: ICAM1; SRD5A1; atherosclerosis; diabetes; peripheral artery disease; single nucleotide polymorphism.

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