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Randomized Controlled Trial
. 2014 Nov 1;19(6):e612-5.
doi: 10.4317/medoral.19778.

Comparative trial between the use of amoxicillin and amoxicillin clavulanate in the removal of third molars

Fernando Iglesias-Martín  1 , Alberto García-Perla-García, Rosa Yañez-Vico, Elena Aced-Jiménez, Esther Arjona-Gerveno, Juan-David González-Padilla, Jose-Luis Gutierrez-Pérez, Daniel Torres-Lagares
Affiliations
Randomized Controlled Trial

Comparative trial between the use of amoxicillin and amoxicillin clavulanate in the removal of third molars

Fernando Iglesias-Martín et al. Med Oral Patol Oral Cir Bucal. .

Abstract

Objective: The purpose of this study was to compare the use of amoxicillin (1g) vs amoxicillin and clavulanate (875/125mg) after extraction of retained third molars for prevention of infectious complications.

Study design: The study involved 546 patients attending for removal a retained third molar and divided in to two groups: Group 1 - amoxicillin and clavunate (875/125mg) group (n=257) and Group 2 - amoxicillin (1g) group (n=289). All patients were recalled for investigating the possibility of infection, presence of diarrhea and further analgesic intake.

Results: From a total of 546 patients, the frequency of infection was 1.4%, without no statistically differences between the two groups. Group 1 showed statistically higher presence of patients with gastrointestinal complications (p>0.05). In 546 patients, 2.7% of patients reported severe pain that would not relieve with medication.

Conclusion: The results of our study show that the use of amoxicillin (1g) and amoxicillin and clavunate (875/125mg) is similar efficacious in preventing infection after retained third molar extraction but amoxicillin and clavunate (875/125mg) produces more gastrointestinal discomfort.

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