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Review
. 2014 Jun;28(3):571-83.
doi: 10.1016/j.hoc.2014.02.001. Epub 2014 Apr 3.

Interferon, interleukin-2, and other cytokines

Elizabeth I Buchbinder  1 , David F McDermott  2
Affiliations
Review

Interferon, interleukin-2, and other cytokines

Elizabeth I Buchbinder et al. Hematol Oncol Clin North Am. 2014 Jun.

Abstract

Cytokines are a diverse group of signaling molecules with immunomodulatory activity. This article reviews the application of cytokine therapy in melanoma with a focus on interferon-α and interleukin-2. In addition, it addresses the clinical considerations of these therapies including patient selection, reduction in toxicity, and combination regimens.

Keywords: Cytokines; Granulocyte-macrophage colony–stimulating factor; Interferon; Interleukin-2; Interleukin-21; Melanoma.

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